Evidence map›Paper›PMID 40844461›Full record

ArticleInfection and immunity2025

Mouse monoclonal antibodies against

Heather K Kroh, Jaime L Jensen, Sabine Wellnitz, Jeong Jin Park, Alexandre Esadze, Kevin W Huynh, Mark Ammirati, Seungil Han, Annaliesa S Anderson, D Borden Lacy and 1 more

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Article
  3. A single amino acid substitution determines susceptibility ofFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heather K KrohDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jaime L JensenDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sabine WellnitzVaccine Research and Development, Pfizer Inc, Pearl River, NewYork, USA.
Jeong Jin ParkVaccine Research and Development, Pfizer Inc, Pearl River, NewYork, USA.
Alexandre EsadzeVaccine Research and Development, Pfizer Inc, Pearl River, NewYork, USA.
Kevin W HuynhDiscovery Sciences, Pfizer Inc, Groton, Connecticut, USA.
Mark AmmiratiDiscovery Sciences, Pfizer Inc, Groton, Connecticut, USA.
Seungil HanDiscovery Sciences, Pfizer Inc, Groton, Connecticut, USA.
Annaliesa S AndersonVaccine Research and Development, Pfizer Inc, Pearl River, NewYork, USA.
D Borden LacyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexey GribenkoVaccine Research and Development, Pfizer Inc, Pearl River, NewYork, USA.ORCID 0000-0002-4285-4608

Funding

Vanderbilt Antibody and Antigen Discovery for Clostridioides difficile VaccinesU19AI174999 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Maribeth Ruth Nicholson · 2023 to 2026
$7.9M
Structural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2M
BLRD VA I01 BX002943NIAID NIH HHS R37 AI095755NIAID NIH HHS U19 AI174999Pfizer Inc. N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingBacterial ProteinsBacterial ToxinsClostridioides difficileEnterotoxinsEpitopesAnimalsHumansMiceAntibodies, MonoclonalAntibodies, NeutralizingBacterial ProteinsBacterial ToxinsEnterotoxinsEpitopestcdA protein, Clostridium difficiletoxB protein, Clostridium difficileC. difficilecryo-EMepitope mappingfunctional assaysmonoclonal antibodiesneutralization assaystoxin Atoxin B

Identifiers

PMID40844461
PMCPMC12519798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.