ArticleEuropean heart journal2025
Sex-specific body fat distribution predicts cardiovascular ageing.
Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- CT-Quantified Sarcopenic Visceral Obesity Is Negatively Associated with Recompensation in Patients with Decompensated Cirrhosis: A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Association of body mass index, waist circumference, (abdominal) overweight and obesity with sex- and age-specific cognitive function over time-the Doetinchem Cohort Study.International journal of obesity (2005) · 2026Article
- Collective exerkines mediate physical activity mitigating new-onset heart failure risk in older adults with prediabetes or diabetes: a community-based longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Dietary patterns in Xinjiang, Western China and associations with metabolic syndrome: a population-based study.Public health nutrition · 2026Article
- Natural Products in the Metabolic and Endocrine Modulation of Polycystic Ovary Syndrome: Current Perspectives.Nutrients · 2026Review
- Managing Obesity in Individuals with Cardiovascular Disease: Are We Missing the Obvious?European cardiology · 2026Review
- Epicardial adipose tissue volume is associated with impaired left atrial mechanics in hypertensive overweight/obese patients: the potential mediating role of insulin resistance.Frontiers in nutrition · 2026Article
- Article
- Association of the triglyceride-glucose series indices with hypertension and pre-hypertension in Anhui China.Scientific reports · 2025Article
- Sex differences in the association between cardiovascular risk factors and coronary artery calcification progression among individuals without coronary artery calcium.Biology of sex differences · 2025Article
- Age-Related Variations in Body Composition and Metabolic Health: A Cross-Sectional Study in Adults.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
aimsCardiovascular ageing is a progressive loss of physiological reserve, modified by environmental and genetic risk factors, that contributes to multi-morbidity due to accumulated damage across diverse cell types, tissues, and organs. Obesity is implicated in premature ageing, but the effect of body fat distribution in humans is unknown. This study determined the influence of sex-dependent fat phenotypes on human cardiovascular ageing.
methodsData from 21 241 participants in the UK Biobank were analysed. Machine learning was used to predict cardiovascular age from 126 image-derived traits of vascular function, cardiac motion, and myocardial fibrosis. An age-delta was calculated as the difference between predicted age and chronological age. The volume and distribution of body fat was assessed from whole-body imaging. The association between fat phenotypes and cardiovascular age-delta was assessed using multivariable linear regression with age and sex as co-covariates, reporting β coefficients with 95% confidence intervals (CI). Two-sample Mendelian randomization was used to assess causal associations.
resultsVisceral adipose tissue volume [β = 0.656, (95% CI, .537-.775), P < .0001], muscle adipose tissue infiltration [β = 0.183, (95% CI, .122-.244), P = .0003], and liver fat fraction [β = 1.066, (95% CI .835-1.298), P < .0001] were the strongest predictors of increased cardiovascular age-delta for both sexes. Abdominal subcutaneous adipose tissue volume [β = 0.432, (95% CI, .269-.596), P < .0001] and android fat mass [β = 0.983, (95% CI, .64-1.326), P < .0001] were each associated with increased age-delta only in males. Genetically predicted gynoid fat showed an association with decreased age-delta.
conclusionsShared and sex-specific patterns of body fat are associated with both protective and harmful changes in cardiovascular ageing, highlighting adipose tissue distribution and function as a key target for interventions to extend healthy lifespan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.