ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025
Increased all-cause mortality following proximal humerus fractures in Danish adults: a register-based matched cohort study of 93,952 fracture cases and 469,760 controls.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Serious adverse events and mortality among adults with non-surgically treated distal radius fractures- a nationwide population-based cohort study of 184,446 Danish patients.BMC musculoskeletal disorders · 2026Article
- Mortality in patients over 65 with proximal humerus fractures: a systematic review of 414,379 shoulders with meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Major Upper-Extremity Fractures in Older Adults: Predictors of 5-Year Mortality.Geriatric orthopaedic surgery & rehabilitation · 2026Article
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6 authors.
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Abstract
Mortality after proximal humerus fractures (PHF) has received less attention compared to hip fractures. We found higher all-cause mortality among PHF patients in Denmark compared to matched controls, with the highest rates within 30 days post-fracture, especially in men. Further research is needed to identify factors associated with this increased mortality. PURPOSE: To assess all-cause mortality among adults with PHFs in Denmark, compared to age- and sex-matched controls from the general population.
methodsThis population-based matched cohort study retrieved data from the Danish National Patient Register and the Danish Civil Registration System from 1998-2018. Adults with a PHF were included and matched 1:5 on age and sex. Outcomes were death at 30 and 90 days, one and two years. Poisson regression analysis accounting for interactions was performed, and age- and sex-specific mortality rates (MRs) per 1,000 persons were calculated for PHFs and controls. Mortality rate-ratios (MRRs) were calculated for all age groups.
resultsWe included 93,952 PHF patients and 469,760 age- and sex-matched controls. Across all time periods, MRs were higher among PHF patients, with MRs consistently higher for men than women. MRs increased with age in both PHF patients and controls. For individuals aged ≥ 60 years, the MRRs among PHF patients and controls were highest within the first 30 days post-fracture, particularly for the age group 60-69 years, where the MRR was 16.32 (95% CI: 14.47-18.40) for males and 7.82 (95% CI: 7.15-8.54) for women. Between 31 and 90 days, the MRR decreased to 6.75 (95% CI: 6.07-7.52) for men and 3.87 (95% CI: 3.58-4.19) for women. After one year, the MRR stabilized and remained relatively unchanged throughout the two-year follow-up.
conclusionDanish patients with PHF demonstrated substantially higher all-cause MRs than their controls, with the highest rates within the first 30 days after the fracture, especially among men.
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