SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Continuous outcomes of robotic-assisted total knee arthroplasty trials are statistically fragile.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Robotic-assisted total knee arthroplasty: accuracy, clinical outcomes, complications, learning curve and cost-effectiveness: a critical clinical review.Journal of robotic surgery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to calculate the continuous fragility index (CFI) of randomized controlled trials (RCTs) assessing outcomes following robotic-assisted total knee arthroplasty (RA-TKA).
methodsMEDLINE, EMBASE, and CENTRAL were searched from inception to April 9, 2024, for RCTs assessing outcomes following RA-TKA compared to conventional total knee arthroplasty (C-TKA). The CFI was calculated for statistically significant outcomes. Multivariable linear regression was performed across the study-level median CFI and various study characteristics.
resultsSeventeen studies (2,636 knees) were included in the final analysis. A total of 110 outcomes were eligible for analysis with a median CFI of 4.5 (IQR, 2.0-8.9). Radiographic outcomes were the most common significant outcome reported (33%, median CFI 7.6 [IQR 4.6-13.2]) followed by inflammatory markers (32%, median CFI 2.4 [IQR 1.0-3.0), operative characteristics (21%, median CFI 7.0 [IQR 4.2-13.7]), subjective outcomes (9%, median CFI 5.2 [IQR 3.1-8.3), and objective outcomes (5%, median CFI 3.1 [IQR 2.2-4.4]). There was a statistically significant difference across the aforementioned categories (p < 0.05). Multivariable linear regression demonstrated that larger sample size ( ß = 0.496, p < 0.0001) and inclusion of inflammatory markers (ß = 0.472, p = 0.015) were correlated with higher study-level median CFI.
conclusionContinuous outcomes across trials assessing RA-TKA versus C-TKA are relatively fragile compared to the orthopaedic literature to date. Radiographic outcomes were the most statistically robust category. The statistical robustness of findings may be limited by RCTs of a small sample size highlighting the importance of future collaborative, multicentre trials. LOE: I.
Indexed as
Identifiers
40844660What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.