ReviewCell biochemistry and biophysics2026
Unlocking the Secrets of Nature: Phytochemicals as Key Players in Longevity and Healthy Aging.
Review in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
1 author.
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Abstract
BACKGROUND/
objectiveThe global aging population presents significant health and societal challenges, driven by age-related disorders including neurodegeneration, cardiovascular disorders, and metabolic syndromes. Phytochemicals show promise in promoting healthy aging and longevity. This study explores their multifaceted roles in mitigating aging hallmarks through molecular, epigenetic, and gut microbiota interactions.
methodsA comprehensive review of current literature (2017–2024) published in PubMed and Scopus, using keywords such as phytochemicals, longevity and aging was conducted, focusing on the biological activities of phytochemicals, their molecular mechanisms, and their role in modulating key aging pathways such as AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and sirtuins. The interaction among phytochemicals and epigenetics, gut microbiome, and their bioavailability challenges were also analyzed.
resultsPhytochemicals exhibit potent antioxidant, anti-inflammatory, and senolytic properties, targeting aging characteristics such as oxidative stress and cellular senescence. Compounds like resveratrol and quercetin influence epigenetic regulation, while others modulate gut microbiota, enhancing therapeutic efficacy. Despite their potential, low bioavailability and interindividual variability remain critical challenges. Emerging delivery systems and personalized approaches show promise for optimizing their benefits.
conclusionPhytochemicals offer a natural, integrative strategy to promote longevity and mitigate age-related diseases by targeting fundamental aging mechanisms. Advancements in clinical validation, bioavailability enhancement, and personalized nutrition are essential to harness their full potential, paving the way for transformative applications in healthy aging interventions.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.