Evidence map›Paper›PMID 40845092›Full record

ArticleScience advances2025

Regulation of feather length: FGF/IGF signaling and NOTCH/YAP modulation of progenitor cell topology.

Ping Wu, Federico Bocci, Christian F Guerrero-Juarez, Chih-Kuan Chen, George Wang, Tzu-Yu Liu, Jiayi Lu, Shu-Man Hsieh Li, Yung-Chih Lai, Ting-Xin Jiang and 5 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ping WuDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0003-0035-8494
Federico BocciDepartment of Mathematics, University of California, Irvine, CA 92697, USA.
Christian F Guerrero-JuarezDepartment of Mathematics, University of California, Irvine, CA 92697, USA.
Chih-Kuan ChenDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-0962-1589
George WangDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0009-0005-7879-3519
Tzu-Yu LiuDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0009-0002-1792-5053
Jiayi LuDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Shu-Man Hsieh LiDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0001-7224-7094
Yung-Chih LaiIntegrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0003-1211-4358
Ting-Xin JiangDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Randall B WidelitzDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Ming-Xing LeiKey Laboratory of Biological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.ORCID 0000-0002-4380-5525
Arthur D LanderDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.ORCID 0000-0002-4380-5525
Qing NieDepartment of Mathematics, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-8804-3368
Cheng-Ming ChuongDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0001-9673-3994

Funding

Size regulation of skin appendagesR01AR047364 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2002 to 2026
$10.1M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Tissue Engineering of New Hair FormationR01AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 2010 to 2019
$4.6M
Tissue Patterning in living skin and organ explantsR37AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2020 to 2026
$3.6M
Multi-scale modulation of organ adaptationR35GM153402 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2024 to 2026
$1.2M
Development of tools for analyzing cell-cell communication using spatial transcriptomic dataR01GM152494 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Zixuan Cang, Qing Nie · 2024 to 2026
$1.0M
NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R01 AR047364NIAMS NIH HHS R01 AR060306NIAMS NIH HHS R37 AR060306NIGMS NIH HHS R01 GM152494NIGMS NIH HHS R35 GM153402
6 · The paper itself

Abstract

The regulation of organ size is a fundamental biological question. This study investigates how feather length is regulated in chickens. We found that collar bulge stem cell zones vary in size: main sickle > lesser sickle > contour feathers. During growth,

Indexed as

FeathersFibroblast Growth FactorsReceptors, NotchSignal TransductionStem CellsAdaptor Proteins, Signal TransducingAnimalsCell DifferentiationChickensYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingFibroblast Growth FactorsReceptors, NotchYAP-Signaling Proteins

Identifiers

PMID40845092
PMCPMC12372877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.