ArticleThe Journal of physiology2025
Theoretical analysis of power-law stress relaxation and calcium-dependent passive mechanics in cardiac muscle.
Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- CaBiophysical journal · 2025Article
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4 authors.
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Abstract
This study investigates the passive viscoelastic properties of cardiac muscle by introducing a theoretical model that explains the observed power-law kinetics of murine cardiac trabeculae passive stress decay. The model accounts for two parallel processes contributing to passive mechanics: an elastic component and a viscoelastic component designed to simulate stress/strain-mediated unfolding of serial domains in the titin molecule. Under stress, serial globular domains within the elastic region of the titin molecule reversibly unfold. This unfolding phenomenon contributes to both hysteresis (a lag in stress between loading and unloading) and preconditioning effects in simulated mechanics. Experimental evidence indicates that stress relaxation in cardiac muscle follows a power law and that the muscle's non-linear stress-strain relationship and hysteresis behaviour are calcium-dependent. To analyse these phenomena, we simulate the apparent viscous element as a mesoscopic-scale ensemble of chains, each composed of serial globular domains that unfold in a stress-dependent manner. The observed increase in passive tension with increased Ca
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