Evidence map›Paper›PMID 40846592›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Targeting Talin1 to reprogram dendritic cell activation landscapes: A mechanistically grounded cell therapy for multiple sclerosis model.

Jia Liu, Xiaorui Guan, Zhen Jia, Bin Li, Yuanbo Cao, Kazuo Sugimoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Altered Erythrocyte Function via TLR9-ox-mtDNA Binding Links Mitochondrial Oxidative Damage to Systemic Inflammation in Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia LiuInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China; Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Xiaorui GuanDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Zhen JiaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Bin LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yuanbo CaoDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Kazuo SugimotoInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China; Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address: a0a172@bucm.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the role of Talin1 in regulating dendritic cell (DC) activation and the neuroprotective benefits of Talin1-knockdown DCs in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Bone marrow-derived DCs (BMDCs) were transduced with shTalin1 lentiviral vectors in vitro. Their morphological and biochemical profiles, surface molecules expression, cytokines production, capacity to induce T cell responses, as well as regulatory mechanisms, were comprehensively assessed. In vivo, Talin1-knockdown BMDCs loaded with the MOG

Indexed as

Cell- and Tissue-Based TherapyDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisTalinAnimalsFemaleMiceMice, Inbred C57BLTalinTln1 protein, mouseDendritic cellsExperimental autoimmune encephalomyelitisImmunomodulationMultiple sclerosisTalin1

Identifiers

PMID40846592
PMCPMC12664513

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.