SynthesisTranslational psychiatry2025
Unraveling consistently altered brain activations of language deficits in schizophrenia: evidence from ALE meta-analysis.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundLanguage deficits are commonly observed in patients with schizophrenia, significantly impacting their quality of life. Current medicine has little curing effects on language deficits in patients with schizophrenia. Therefore, it is crucial to investigate the underlying pathology of these deficits and unravel the potential intervention targets.
methodsWe systematically reviewed fMRI publications on language processing in schizophrenia and summarized the evidence quantitatively with activation likelihood estimation algorithms following PRISMA guidelines. A total of 82 experiments involving 1538 schizophrenia patients and 1413 healthy controls were included in the current study.
resultsOur findings revealed that the left middle frontal gyrus (MFG) and inferior frontal gyrus (IFG) were consistently related to language deficits in schizophrenia across all modalities and all contrasts. Subsequent analysis revealed increased activation in the left MFG related to language deficits in schizophrenia. Subgroup analyses uncovered modality-specific alterations. Specifically, reduced activation in bilateral MFG in language comprehension, and increased activation in left IFG in language production in schizophrenia. Further evidence in comparison analysis also uncovered greater alteration in right MFG related to comprehension than production, while greater alterations in left IFG and others related to production than comprehension in schizophrenia. Moreover, we found that age modulates the altered activation patterns in schizophrenia, while positive or negative symptoms, or sex, did not show significant correlations with these patterns.
conclusionsIn summary, our study highlights convergent altered activation patterns in specific brain regions and identifies several heterogeneous sources (e.g., language modality, age) contributing to language deficits in schizophrenia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.