Evidence map›Paper›PMID 40846913›Full record

ReviewBMC nephrology2025

Biocompatibility in hemodialysis: artificial membrane and human blood interactions.

Eduardo Ávila, Rodrigo A Sepúlveda, Jaime Retamal, Daniel Hachim

Abstract readReview
In one paragraph

Review in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eduardo ÁvilaDepartment of Nephrology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.ORCID 0009-0007-6587-7021
Rodrigo A SepúlvedaDepartment of Nephrology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.ORCID 0000-0002-9618-3686
Jaime RetamalDepartment of Intensive Medicine, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica, Santiago, Chile.ORCID 0000-0002-6817-3659
Daniel HachimDepartment of Pharmacy, School of Pharmacy, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago, Chile. djhachim@uc.cl.ORCID 0000-0002-6898-9009

Funding

Agencia Nacional de Investigación y Desarrollo 11240633Agencia Nacional de Investigación y Desarrollo 1241897Agencia Nacional de Investigación y Desarrollo 21231166
6 · The paper itself

Abstract

Hemodialysis, a cornerstone therapy for chronic kidney disease, represented a crucial advance in the evolution of artificial organs. While its success is largely due to its efficiency in removing uremic toxins, an equally important challenge is to uphold the primum non nocere principle by minimizing the harmful effects of membrane-blood interactions. This review examines the complex mechanisms and key interactions underlying membrane biocompatibility, including complement activation, inflammation, and coagulation disturbances, paving the way for their clinical implications. We also summarize recent innovations in membrane materials and surface engineering aimed at improving hemocompatibility and promoting safer hemodialysis treatments for improved clinical outcomes.

Indexed as

Biocompatible MaterialsMembranes, ArtificialRenal DialysisBlood CoagulationComplement ActivationHumansBiocompatible MaterialsMembranes, Artificial

Identifiers

PMID40846913
PMCPMC12374333

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.