Evidence map›Paper›PMID 40847110›Full record

ArticleScientific reports2025

DNA aptamer Apt

Katherin Peñaranda, Nicolle Pereira, Orestis Savva, Dezemona Petrelli, Roberto Spurio, Rebecca M Corrigan, Pohl Milon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherin PeñarandaLaboratory of Biomolecules, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas (UPC), 15023, Lima, Peru. katherin.penaranda@upc.pe.
Nicolle PereiraLaboratory of Biomolecules, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas (UPC), 15023, Lima, Peru.
Orestis SavvaSchool of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.
Dezemona PetrelliLaboratory of Genetics, School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
Roberto SpurioLaboratory of Genetics, School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
Rebecca M CorriganSchool of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.
Pohl MilonLaboratory of Biomolecules, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas (UPC), 15023, Lima, Peru. pmilon@upc.edu.pe.

Funding

BBSRC DTP studentship grant BB/T007222/1Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica PE501079419-2022Horizon 2020 Marie Sklodowska-Curie Grant Agreement No. 872869Wellcome TrustWellcome Trust 104110/Z/14/A
6 · The paper itself

Abstract

Ribosome assembly is a multistep process that ensures a functional ribosome structure. The molecular mechanism that ribosome-associated GTPases (RA-GTPases) use to enhance ribosome assembly accuracy remains largely to be elucidated. Here, we use systematic evolution of ligands by exponential enrichment (SELEX), followed by sequencing, comprehensive bioinformatics analysis, and biochemical characterization to identify aptamers that target the RA-GTPase ERA of Staphylococcus aureus. ELONA and thermophoresis assays show that the Apt

Indexed as

Aptamers, NucleotideBacterial ProteinsGTP PhosphohydrolasesGuanosine TriphosphateStaphylococcus aureusHydrolysisMolecular Docking SimulationProtein BindingRibosomesRNA, Ribosomal, 16SSELEX Aptamer TechniqueAptamers, NucleotideBacterial ProteinsGTP PhosphohydrolasesGuanosine TriphosphateRNA, Ribosomal, 16SAptamerERAGTPaseRibosome assemblySELEX

Identifiers

PMID40847110
PMCPMC12373895

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.