Evidence map›Paper›PMID 40847348›Full record

ArticleMolecular brain2025

Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis.

Ryo Miyake, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Takeru Ueno, Yuta Kaimochi, Terumasa Nakatsuka, Hiroshi Yamada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryo MiyakeDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
Manabu YamanakaDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan. musagoro@wakayama-med.ac.jp.
Wataru TaniguchiDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
Naoko NishioDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
Yuki MatsuyamaDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
Takeru UenoDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
Yuta KaimochiDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
Terumasa NakatsukaPain Research Center, Kansai University of Health Sciences, Osaka, Japan.
Hiroshi YamadaDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such changes occur in knee OA mice and their association with exercise therapy remains unclear. Therefore, this study investigated these aspects using electrophysiological and behavioral approaches. We found no induction of pre- or post-long-term potentiation (LTP) in the ACC of knee OA mice. Application of ZD7288 and zeta inhibitory peptide (ZIP) reduced the amplitude of evoked excitatory postsynaptic currents, indicating pre-existing changes in synaptic plasticity in the ACC. Microinjection of ZD7288 and ZIP improved pain-escape and anxiety-like behaviors. Voluntary running exercise induced pre- and post-LTP and improved these behaviors in knee OA mice. Exercise therapy for knee OA may alter synaptic plasticity in the ACC, contributing to behavioral improvements.

Indexed as

Gyrus CinguliOsteoarthritis, KneePhysical Conditioning, AnimalRunningSynapsesAnimalsAnxietyBehavior, AnimalExcitatory Postsynaptic PotentialsLong-Term PotentiationMaleMiceMice, Inbred C57BLNeuronal PlasticityAnterior cingulate cortexChronic painExercise therapyOsteoarthritis of the kneePain-escapePost-long-term potentiationPre-long-term potentiationSynaptic plasticityVoluntary running

Identifiers

PMID40847348
PMCPMC12374455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.