Evidence map›Paper›PMID 40847608›Full record

ArticleParasite immunology2025

Lycopene Mitigates Malaria-Induced Reactive Oxygen and Nitrogen Species and Oxidative Damage in Mice Brain and Lungs.

Everton Luiz Pompeu Varela, Antônio Rafael Quadros Gomes, Aline da Silva Barbosa Dos Santos, Mariana Dos Santos Guimarães, Eliete Pereira de Carvalho, Oberdan Oliveira Ferreira, Mozaniel Santana de Oliveira, Marcello Iriti, Eloisa Helena de Aguiar Andrade, Sandro Percário

Abstract read
In one paragraph

Article in Parasite immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Everton Luiz Pompeu VarelaOxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0001-9710-3791
Antônio Rafael Quadros GomesOxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0002-4700-7942
Aline da Silva Barbosa Dos SantosOxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0003-4125-4392
Mariana Dos Santos GuimarãesOxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0002-7175-2731
Eliete Pereira de CarvalhoOxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0003-1454-9638
Oberdan Oliveira FerreiraAdolpho Ducke Laboratory, Botany Coordination, Museu Paraense Emílio Goeldi, Belém, Pará, Brazil.ORCID 0000-0002-7881-8625
Mozaniel Santana de OliveiraLaboratory of Pharmacology of Inflammation and Behavior, Postgraduate Program in Pharmaceutical Sciences, Institute of Health Sciences, Federal University of Pará, Belém, Brazil.ORCID 0000-0002-4076-2443
Marcello IritiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.ORCID 0000-0002-5063-1236
Eloisa Helena de Aguiar AndradePostgraduate Program in Biodiversity and Biotechnology - BIONORTE Network, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0003-0640-7496
Sandro PercárioOxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0002-9528-0361

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Brazil)Fundação Amazônia Paraense de Amparo à Pesquisa (FAPESPA; Brazil)
6 · The paper itself

Abstract

The severity of malaria is associated with low antioxidant availability and elevated free radical production, which induces oxidative damage in cerebral and pulmonary microcirculation. This can be mitigated by dietary antioxidants. We investigated the protective effects of lycopene (LYC) against oxidative changes induced by Plasmodium berghei (Pb). Mice were infected by intraperitoneal injection of 10

Indexed as

AntioxidantsBrainCarotenoidsLungMalariaOxidative StressReactive Nitrogen SpeciesReactive Oxygen SpeciesAnimalsDisease Models, AnimalFemaleLycopeneMaleMiceNitric OxidePlasmodium bergheiAntioxidantsCarotenoidsLycopeneNitric OxideReactive Nitrogen SpeciesReactive Oxygen SpeciesThiobarbituric Acid Reactive SubstancesantioxidantlycopenemalariaN‐acetylcysteineoxidative stress

Identifiers

PMID40847608
PMCPMC12374180

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.