Evidence map›Paper›PMID 40847618›Full record

ArticleBrain pathology (Zurich, Switzerland)2026

Nitro-oleic acid activation of endothelial PPARγ signaling pathway alleviates neurovascular injury and improves functional outcomes in ischemic stroke.

Tianqing Xiong, Na Qiu, Andrew Ni, Xiaotao Xu, Ping Sun, Shun Li, Ke-Jie Yin

Abstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianqing XiongGeriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6497-7847
Na QiuGeriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Andrew NiDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Xiaotao XuDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ping SunGeriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6307-3723
Shun LiGeriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-8601-2261
Ke-Jie YinGeriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-7169-3858

Funding

Long non-coding RNAs mediate white and grey matter integrity in vascular cognitive impairment and dementiaR01NS136154 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kejie Yin · 2024 to 2026
$1.9M
Targeting Kruppel-like Transcription Factor for White and Grey Matter Protection in Vascular Cognitive Impairment and DementiaR01NS131122 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kejie Yin · 2023 to 2026
$1.9M
American Heart Association 23TPA1068534BLRD VA I01 BX004837BLRD VA I01 BX005750NIH HHS R01NS131122NIH HHS R01NS136154NINDS NIH HHS R01 NS131122NINDS NIH HHS R01 NS136154VA Pittsburgh Healthcare System I01BX004837VA Pittsburgh Healthcare System I01BX005750
6 · The paper itself

Abstract

Nitro-oleic acid (OA-NO

Indexed as

Ischemic StrokeOleic AcidsPPAR gammaAnimalsBlood-Brain BarrierBrain IschemiaEndothelial CellsInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMice, KnockoutSignal Transduction10-nitro-oleic acidOleic AcidsPPAR gammaPparg protein, mouseblood–brain barriercerebral inflammationendothelial PPARγischemic strokeOA‐NO2

Identifiers

PMID40847618
PMCPMC12695680

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.