Evidence map›Paper›PMID 40847889›Full record

ArticleAnnals of medicine2025

Predominance of gram-negative multidrug-resistant pathogens causing lower respiratory tract infections among gene X-pert negative presumptive tuberculosis patients in Dar Es Salaam, Tanzania.

Irene Rabiel, Mtebe Majigo, Loveness Urio, Lilian Nkinda, Peter Richard Torokaa, Elieshiupendo M Niccodem, Mabula Kasubi, Doreen Kamori, Joel Manyahi, Agricola Joachim

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Irene RabielDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Mtebe MajigoDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0003-3726-2816
Loveness UrioTanzania Field Epidemiology and Laboratory Training Program, Dar es Salaam, Tanzania.
Lilian NkindaDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Peter Richard TorokaaDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0009-0003-3843-3434
Elieshiupendo M NiccodemDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0001-6469-779X
Mabula KasubiDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Doreen KamoriDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0001-5162-6554
Joel ManyahiDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0002-1388-3901
Agricola JoachimDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0002-1024-8072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLower respiratory tract infections (LTRIs) represent a significant global health burden. The clinical presentation of pulmonary tuberculosis (PTB) and other LRTIs often overlap, making it difficult to differentiate based on clinical features only. This study aims to investigate the role of other bacteria pathogens in LRTIs among presumptive TB patients and antibiotic susceptibility patterns for appropriate patient management. MATERIALS AND

methodsWe conducted a cross-sectional study among patients with symptoms and signs suggestive of PTB at Muhimbili National Hospital and Infectious Diseases Centre in Dar es Salaam, Tanzania. Sputum samples collected for TB diagnosis using the original GeneXpert system were investigated for other causes of LRTIs. The sputum samples were assessed for quality based on the Bartlett criteria before culture. We performed descriptive statistics to summarize the data.

resultsWe assessed 470 sputum samples, of which 317(67.4%) were of good quality. Of 317 samples, 21(6.6%) were

conclusionThis study revealed a high prevalence of LRTIs caused by non-TB pathogens, particularly MDR strains in presumptive TB. MTB was detected only in high‑quality sputum samples. The high resistance rate to commonly prescribed antibiotics for LRTIs called for further large-scale studies to guide and/or refine treatment guidelines and optimize patient care.

Indexed as

Gram-Negative BacteriaGram-Negative Bacterial InfectionsRespiratory Tract InfectionsTuberculosis, PulmonaryAdolescentAdultAgedAnti-Bacterial AgentsCross-Sectional StudiesDrug Resistance, Multiple, BacterialFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisAnti-Bacterial AgentsAntibiotic susceptibility testingGeneXpertlower respiratory tract infectionpresumptive tuberculosissputum quality

Identifiers

PMID40847889
PMCPMC12377089

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.