Evidence map›Paper›PMID 40848219›Full record

ArticleJournal of ultrasound2025

Pancreatic 2D SWE: a potential tool for non-invasive evaluation of diabetes and diabetic microangiopathy?

Lakshmi Shri Sivaraju, Rashmi Dixit, Anjali Prakash, Sandeep Garg, Paromita Dutta

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Article in Journal of ultrasound, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Lakshmi Shri SivarajuDepartment of Radiodiagnosis, Maulana Azad Medical College, New Delhi, 110002, India. lakshmishrisivaraju@gmail.com.ORCID http://orcid.org/0009-0002-7452-4651
Rashmi DixitDepartment of Radiodiagnosis, Maulana Azad Medical College, New Delhi, 110002, India.
Anjali PrakashDepartment of Radiodiagnosis, Maulana Azad Medical College, New Delhi, 110002, India.
Sandeep GargDepartment of Medicine, Maulana Azad Medical College & Associated Hospitals, New Delhi, India.
Paromita DuttaDepartment of Ophthalmology, Guru Nanak Eye Centre, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the pancreatic stiffness values in non-diabetics and diabetic patients using ultrasound shear wave elastography and to associate shear wave elastography values with the presence of diabetic microangiopathy.

methodsThe study included 133 adult participants with 50 non-diabetics and 83 diabetics. Among 83 diabetics, 42 were without and 41 were with diabetic microangiopathy. Pancreatic stiffness was assessed using 2D shear-wave elastography (SWE), with values expressed in kilopascals (kPa) and meters per second (m/s). Measurement reliability was ensured by maintaining an interquartile range-to-median ratio (IQR/M) of ≤ 30% for kPa and ≤ 15% for m/s.

resultsPancreatic stiffness measured by 2D shear wave elastography was significantly higher in diabetic patients compared to non-diabetic participants, with further elevated values observed in those with microangiopathy. Stiffness values increased proportionally with the number of microangiopathies, with the highest values seen in patients with multiple microangiopathies. ROC curve analysis revealed cutoff values of pancreatic stiffness for predicting diabetes and microangiopathy, demonstra0ting high sensitivity and specificity, with higher stiffness thresholds correlating with the presence of microangiopathy.

conclusionThese findings highlight the utility of 2D shear wave elastography as a valuable, non-invasive imaging tool for the assessment of pancreatic changes in diabetes and its associated microangiopathic complications.

Indexed as

Diabetes MellitusDiabetic AngiopathiesElasticity Imaging TechniquesPancreasAdultAgedFemaleHumansMaleMiddle AgedReproducibility of ResultsSensitivity and SpecificityDiabetesMicroangiopathyPancreatic stiffnessShear wave elastography

Identifiers

PMID40848219
PMCPMC12675893

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