SynthesisJournal of neurology2025
Functional exercise training in persons with multiple sclerosis: a systematic review.
Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Combined Whole-Body Cryotherapy and Exercise vs Exercise Alone for Lower Limb Strength and Mobility in Multiple Sclerosis.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional exercise training focuses on enhancing the body's capacity for everyday movements by targeting a combination of strength, stability, balance, coordination, and flexibility. More flexible and less standardized exercise approaches, such as functional exercise training, may offer further benefits on improving symptoms in persons with MS (pwMS), but they have been less investigated. This review aims to provide a comprehensive overview of the existing literature on the effects of functional exercise training on functional outcomes (mobility, walking capacity, balance, and proprioception), physical (strength and endurance) and physiological performance measures, as well as patient-reported outcomes (Quality of Life, Fatigue) in pwMS. The systematic review was conducted according to the PRISMA guidelines. Literature searches were conducted in Medline (PubMed) and Cochrane CENTRAL (inception to 19th February 2025). We included studies investigating the effects of functional exercise training on any outcome in adult pwMS. The quality and reporting were evaluated using the Tool for the assEssment of Study qualiTy and reporting in EXercise (TESTEX). A total of 19 studies were included in the review, ranging from smaller pilot studies to larger randomized controlled trials. Interventions lasted between six and 16 weeks. Results of the studies included in this review were highly heterogeneous. Some of the included studies have demonstrated improvements in mobility, short and long walking capacity, balance, strength, and endurance measures as well as on quality of life and fatigue. Adherence to training was poorly reported. Functional exercise training for pwMS is a comprehensive approach to achieving functional improvements, strength gains, and improved endurance simultaneously, thereby promoting beneficial health effects. In future, a clear definition of functional exercise training is required, research should focus on the consistent reporting of treatment adherence, and investigate the long-term effects of functional exercise training in pwMS.PROSPERO registration number: CRD42023448077.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.