ArticleBMC nephrology2025
Association between tonsillectomy plus steroid pulse therapy and renal outcomes in patients with IgA nephropathy: a retrospective cohort study.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIgA nephropathy (IgAN) is the most common disorder in chronic glomerulonephritis, and various treatment methods have been established. Tonsillectomy and steroid pulse therapy (TSP) are widely performed in Japan. However, their correlation with renal outcomes remains unclear. In this study, we aimed to examine the association between renal prognosis and steroid pulse therapy with or without tonsillectomy.
methodsIn this retrospective cohort study, we identified patients diagnosed with IgAN between April 2002 and March 2021 using a Japanese healthcare records database. We selected patients with a prescription history of methylprednisolone for three consecutive days within one year of diagnosis and an estimated glomerular filtration rate (eGFR) of 30 mL/min/1.73 m
resultsOverall, 550 patients were eligible for the main analysis, and approximately 40% underwent tonsillectomy within 1 year of IgAN diagnosis: 221 in the TSP group and 329 in the SP group. The primary outcome did not differ between the groups (hazard ratio, 0.58; [95% confidence interval: 0.22-1.54]; P = 0.28). The groups did not differ in terms of the secondary outcomes.
conclusionsAlthough we could not demonstrate the effectiveness of TSP on renal prognosis in patients with IgAN, this study may have been underpowered, and there are certain limitations due to the information available from the database, we were able to evaluate the association of TSP on renal outcomes using real-world data. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.