ArticleJournal of nanobiotechnology2025
Nanoengineered hydrogels disrupt tumor antioxidant defense via photothermal-chemodynamic synergy and oxidative stress boosts.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death.Phytotherapy research : PTR · 2026Review
- Spatiotemporally controlled delivery of biomacromolecules via injectable hydrogels for precision modulation of the tumor immune microenvironment.Journal of nanobiotechnology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
By integrating photothermal and chemodynamic properties, Ru-based nanomaterials have emerged as promising agents for tumor therapy. However, their clinical translation is hindered by high systemic toxicity, suboptimal therapeutic efficacy, and compromised chemodynamic performance caused by tumor antioxidant defense mechanisms. A multifunctional therapeutic platform (Ru-PC-PEITC-ALG) was developed through the coordination-driven self-assembly of ruthenium ions with procyanidins (PCs) to form Ru-PC nanoparticles, followed by coencapsulation with phenethyl isothiocyanate (PEITC) in a sodium alginate hydrogel. The Ru-PC complex demonstrated exceptional photothermal conversion efficiency, enabling rapid intratumoral temperature elevation under 808 nm laser irradiation to achieve localized thermal ablation. Simultaneously, Ru-PC exhibited tumor microenvironment-responsive catalytic activity, catalyzing the conversion of hydrogen peroxide (H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.