ArticleScientific reports2025
Repeated theta burst stimulation of the right ventrolateral prefrontal cortex reveals strong habituation in the context of stress and rumination.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Investigating the neural and behavioral correlates of the stress-rumination link in healthy humans by modulating the left Dorsolateral Prefrontal Cortex using Theta Burst Stimulation.Cognitive, affective & behavioral neuroscience · 2025Trial
- Rumination Out Loud? Linguistic, Neural, and Psychophysiological Correlates of the Think-Aloud Paradigm.Depression and anxiety · 2026Article
- Immersive metaverse art as a psychological intervention for depression and anxiety: a narrative review and multilevel model integrating engagement, cultural identity, and neurocognitive mechanisms.Frontiers in psychology · 2026Review
- Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation.Neurobiology of stress · 2025Article
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Authors and funding
13 authors.
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Abstract
Prefrontal hypoactivation under stress has been consistently observed in individuals with high trait rumination and in patients with depression. However, no study has yet investigated the mechanisms of modulating activity of the Ventrolateral Prefrontal Cortex (VLPFC) by using excitatory and inhibitory Theta Burst Stimulation (TBS) in this context. To address this, we recruited 89 healthy participants (44 low trait ruminators and 45 high trait ruminators) who attended two lab sessions, each including stress induction via the Trier Social Stress Test (TSST). Participants received either excitatory intermittent TBS (iTBS) or inhibitory continuous TBS (cTBS). One session involved active TBS, while the other used sham TBS (sTBS), with the order randomized and balanced across stimulation conditions and groups. In high ruminators, we observed a significant impact of iTBS in the hypothesized direction when considering cortical oxygenation in the right VLPFC. We found higher subjective stress following iTBS and cTBS compared to sTBS during recovery of the TSST but only at the first appointment. No stimulation-dependent effects were found for other measures (state rumination, positive and negative affect, and heart rates). In our discussion, we draw conclusions concerning repeated-measures designs in TBS-studies.
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