ArticleBMC geriatrics2025
Aging and liver health: liver chemistries and associated factors in community-dwelling older adults.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03240952 (Establishing Reference Range for Community-dwelling Elderly Nutrition), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishing Reference Range for Community-dwelling Elderly Nutrition
Who cites it
2 citing papers in PubMed.
- Impact of Mildly Elevated Alanine Transaminase on In-Hospital Outcomes and Statin Intolerance in Elderly Patients With Acute Myocardial Infarction: A Retrospective Cohort Study.Cardiology research and practice · 2025Article
- Hybrid intelligent systems for liver disease prediction: a demographic-aware machine learning framework.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundLiver chemistries are used to measure liver function or damage, and it is vital to differentiate between the changes due to aging versus other causes. The literature has also reported a decline in serum alanine transaminase (ALT) in older age independent of other factors. In this study, we seek to (1) evaluate liver chemistries in healthy community-dwelling older adults, and (2) investigate the associations with age, sex, use of statins, and other factors.
methodsThis cross-sectional study included 400 older adults aged ≥ 65 years with normal nutritional status and who took part as a non-randomized reference group in the Strengthening Health In ELDerly through nutrition (SHIELD) study. Blood samples were analyzed for ALT, aspartate transaminase (AST), albumin, total bilirubin, alkaline phosphatase (ALP), total protein, and globulin. Analysis of variance and multiple linear regression models were used to evaluate the desired associations.
resultsMean values of all the liver chemistries were within normal laboratory reference ranges for both sex and age categories. Males had higher ALT, albumin, and total bilirubin than females (all P ≤ 0.023), whereas females had higher ALP and globulin than males (both P ≤ 0.015). Participants aged 65 to < 75 years had higher ALT and lower total bilirubin than those aged ≥ 75 years (both P ≤ 0.020). There was a significant relationship between ALP and intensity of statin therapy (P = 0.023), in which high-intensity statin therapy had significantly higher ALP than low-intensity statin therapy (P = 0.045). However, these values were still within the normal range for ALP.
conclusionsLiver chemistries in community-dwelling older adults with normal nutritional status were within the normal reference range used for adults. There were small but statistically significant differences with age, sex, and intensity of statin therapy. ALT declined with age, and further prospective studies are required to determine cut-offs for increased risk of adverse clinical outcomes.
trial registrationNCT03240952.
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