Evidence map›Paper›PMID 40849822›Full record

ReviewOncology reports2025

Role of autophagy‑modulating long non‑coding RNAs in tumor radioresistance (Review).

Hailong Li, Zhengxi He

Abstract readReview
In one paragraph

Review in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hailong LiDepartment of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan 415000, P.R. China.
Zhengxi HeDepartment of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy improves survival rates in patients with cancer; however, the development of radioresistance hinders its effectiveness, resulting in unfavorable outcomes. A key factor in cancer progression is the dysregulation of autophagy, a lysosomal degradation process governed by various evolutionarily conserved autophagy‑related genes (ATGs). Long non‑coding RNAs (lncRNAs) serve a crucial role in the regulation of autophagy. lncRNAs modulate ATGs and their signaling pathways, contributing to the emergence of radioresistance. The present review offers a comprehensive examination of the critical roles of autophagy and lncRNAs in mediating radioresistance. By enhancing the understanding of these mechanisms, novel therapeutic strategies aimed at increasing tumor radiosensitivity through the modulation of autophagy may be revealed.

Indexed as

AutophagyNeoplasmsRadiation ToleranceRNA, Long NoncodingAnimalsAutophagy-Related ProteinsGene Expression Regulation, NeoplasticHumansSignal TransductionAutophagy-Related ProteinsRNA, Long Noncodingautophagycancerlong non‑coding RNAradioresistance

Identifiers

PMID40849822
PMCPMC12402759

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.