ArticleDigestive diseases and sciences2026
Clinical Efficacy of Ursodeoxycholic Acid in Bile Reflux Gastritis: A Systematic Review and Meta-Analysis.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Billroth II With Braun Anastomosis Versus Roux-En-Y Reconstruction Following Distal Gastrectomy: A Systematic Review and Meta-Analysis.World journal of surgery · 2026Pooled it
- Predisposing factors and histopathological changes in duodenogastric reflux: a retrospective case-control study.BMC gastroenterology · 2026Article
- Reply to "Insights on Relationship of Blood Glucose Control and the Prognosis of Acute Pancreatitis".Digestive diseases and sciences · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundBile reflux gastritis (BRG) may lead to precancerous lesions of gastric cancer and gastric cancer. Although ursodeoxycholic acid (UDCA) has been used to treat BRG, its clinical efficacy remains unknown. Therefore, we systematically evaluated the efficacy and safety of UDCA compared with conventional therapy for BRG.
methodsWe selected candidate studies and generated a forest plot to evaluate outcomes. Metaregression analysis was conducted to identify possible explanations for heterogeneity. Study quality was evaluated using the Cochrane Risk of Bias 2 tool and the Newcastle-Ottawa scale. The quality of evidence for the outcomes of the meta-analysis was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.
resultsA total of 14 studies including 1605 patients were identified. Compared with control groups, medication combined with UDCA significantly reduced the number of reflux episodes [mean difference (MD) = - 17.99 times, 95% CI (- 19.84, - 16.14)], shortened the longest duration of reflux [MD = - 9.21 min, 95% CI (- 12.63, - 5.80)], decreased the number of long reflux episodes [MD = - 3.21 times, 95% CI (- 3.76, - 2.66)], increased the clinical response rate [risk ratio = 1.15, 95% CI (1.10, 1.19)], decreased the gastrin content [MD = - 18.03 ng/L, 95% CI (- 33.88, - 2.18)] and alleviated symptoms.
conclusionsUDCA demonstrates significant therapeutic efficacy for BRG, particularly with 8-week regimens, supporting its potential as a first-line therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.