Evidence map›Paper›PMID 40849909›Full record

ArticleCell reports2025

Striatal output regulates the postnatal maturation of cortical circuits.

Michael Janeček, Tara Deemyad, Yi-Chun Shih, Vicente Valle, Andrew D'Agostino, Michael Matarazzo, Megan S Perez, Kyle D Ketchesin, Susana da Silva, Rui T Peixoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Michael JanečekDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA; Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA.
Tara DeemyadDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA.
Yi-Chun ShihDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA; Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA.
Vicente ValleDepartment of Ophthalmology, University of Pittsburgh, 1622 Locust St., Pittsburgh, PA 15219, USA.
Andrew D'AgostinoDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA.
Michael MatarazzoDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA.
Megan S PerezDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kyle D KetchesinDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA; Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA.
Susana da SilvaDepartment of Ophthalmology, University of Pittsburgh, 1622 Locust St., Pittsburgh, PA 15219, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Rui T PeixotoDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA; Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: peixotort@upmc.edu.

Funding

Mechanisms and pathogenic role of early corticostriatal dysfunction in Shank3B-/- miceR01MH124695 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEIXOTO, RUI · 2021 to 2025
$2.0M
Role of retinoic acid signaling in fovea developmentR01EY033385 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Susana Isabel M M A da Silva · 2022 to 2026
$2.0M
Role of DNA methylation in regulating striatal molecular rhythm alterations in depressionK01MH128763 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KETCHESIN, KYLE · 2021 to 2024
$680k
Role of local interneurons in early cortical dysfunction in Shank3 KO miceR21MH132015 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEIXOTO, RUI · 2023 to 2023
$437k
NEI NIH HHS R01 EY033385NIMH NIH HHS K01 MH128763NIMH NIH HHS R01 MH124695NIMH NIH HHS R21 MH132015
6 · The paper itself

Abstract

The dorsomedial prefrontal cortex (dmPFC) and basal ganglia (BG) are tightly interconnected through cortico-BG-thalamocortical (CBGT) loops that undergo extensive refinement during postnatal development. While the role of cortical activity in shaping striatal circuit maturation is well established, the extent to which the BG regulate dmPFC development remains unclear. Here, we examined whether early striatal output influences the maturation of dmPFC activity and connectivity. Targeted ablation of direct or indirect pathway spiny projection neurons during the first two postnatal weeks induced bidirectional changes in dmPFC neural activity akin to BG modulation of cortical dynamics observed in mature circuits. Interestingly, these manipulations also disrupted synaptic maturation of layer 2/3 pyramidal neurons, shifting the balance between excitation and inhibition. Together, these findings demonstrate that striatal output regulates cortical activity during early postnatal development and suggest a previously unrecognized role for the BG in guiding the establishment of prefrontal cortical networks.

Indexed as

Corpus StriatumNerve NetPrefrontal CortexAnimalsBasal GangliaMiceNeural PathwaysPyramidal CellsBasal gangliacalcium imagingcortico-basal ganglia-thalamic circuitsCP: Neurosciencedirect and indirect pathwaysexcitation-inhibition balancepostnatal developmentprefrontal cortexspiny projection neuronsstriatal outputsynaptic maturation

Identifiers

PMID40849909
PMCPMC12515399

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.