Evidence map›Paper›PMID 40850368›Full record

ArticleMetabolic engineering2026

Lipid accumulation in nitrogen and phosphorus-limited yeast is caused by less growth-related dilution.

Xi Li, Daniel R Weilandt, Felix C Keber, Arjuna M Subramanian, Shayne R Loynes, Christopher V Rao, Yihui Shen, Martin Wühr, Joshua D Rabinowitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Leveraging 13C-Labeling to Assign Molecular Formulas to Unknown Yeast Metabolites.Journal of the American Society for Mass Spectrometry · 2026
    Article
  2. Morphological Shift and Lipid Accumulation inJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. High Cell Density Fermentation ofInternational journal of molecular sciences · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xi LiDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, United States; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, Princeton University, Princeton, NJ, 08544, United States.
Daniel R WeilandtDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, United States; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, 08544, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, Princeton University, Princeton, NJ, 08544, United States.
Felix C KeberLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, United States.
Arjuna M SubramanianDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, United States; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States.
Shayne R LoynesDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, United States; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, Princeton University, Princeton, NJ, 08544, United States.
Christopher V RaoDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana-Champaign, Urbana, IL, 61801, United States.
Yihui ShenDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, United States; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States.
Martin WührLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, United States.
Joshua D RabinowitzDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, United States; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, United States; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, 08544, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, Princeton University, Princeton, NJ, 08544, United States. Electronic address: joshr@princeton.edu.

Funding

Development of New Proteomics Technology and its Application to Study Cellular OrganizationR35GM128813 · NIGMS · PRINCETON UNIVERSITY · PI Martin Wühr · 2018 to 2026
$4.0M
NIGMS NIH HHS R35 GM128813
6 · The paper itself

Abstract

Oleaginous yeasts are used commercially to produce oleochemicals and hold potential also for biodiesel production. In response to nitrogen or phosphorous limitation, oleaginous yeasts accumulate lipids in the form of triacylglycerols. Previous work has investigated potential mechanisms by which nutrient limitation induces lipid biosynthesis without verifying whether lipid biosynthesis flux is actually enhanced. Here we show, using

Indexed as

Lipid MetabolismLipidsNitrogenPhosphorusRhodotorulaYarrowiaFungal ProteinsFungal ProteinsLipidsNitrogenPhosphorusBiodieselde novo lipogenesisIsotope tracingKinetic flux profilingOleaginous yeast

Identifiers

PMID40850368
PMCPMC12721721

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.