Evidence map›Paper›PMID 40852158›Full record

ArticleFood science & nutrition2025

Characterization and Optimization of L-Asparaginase Production by

Wassima Lakhdari, Salah Neghmouche Nacer, Ibtissem Benyahia, Hamida Hammi, Hakim Bachir, Djawahir Mouhoubi, Yasmine Lakhdari, Ihsane Guemmou, Abderrahmene Dehliz, Barbara Sawicka and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wassima LakhdariNational Institute of Agronomic Research of Algeria Station of Sidi Mehdi Touggourt Algeria.
Salah Neghmouche NacerDepartment of Chemistry, Faculty of Exact Sciences University of El Oued El-Oued Algeria.
Ibtissem BenyahiaLaboratory of Biogeochemistry and Desert Environments, Department of Chemistry, Faculty of Mathematics and Material Sciences University of Kasdi Merbah Ouargla Algeria.
Hamida HammiDivision of Hydraulic and Bioclimatology National Institute of Agronomic Research (INRA) Algers Algeria.
Hakim BachirDivision of Hydraulic and Bioclimatology National Institute of Agronomic Research (INRA) Algers Algeria.
Djawahir MouhoubiSARL SINAL Oran Algeria.
Yasmine LakhdariFaculty of Natural, Life and Earth Sciences Ghardaia University Ghardaia Algeria.
Ihsane GuemmouSARL SINAL Oran Algeria.
Abderrahmene DehlizNational Institute of Agronomic Research of Algeria Station of Sidi Mehdi Touggourt Algeria.
Barbara SawickaDepartment of Plant Production Technology and Commoditties Science University of Life Sciences in Lublin Lublin Poland.ORCID https://orcid.org/0000-0002-8183-7624
Sheikh F AhmadDepartment of Pharmacology and Toxicology, College of Pharmacy King Saud University Riyadh Saudi Arabia.
Sabry M AttiaDepartment of Pharmacology and Toxicology, College of Pharmacy King Saud University Riyadh Saudi Arabia.
Amar DjemouiLaboratory of Organic Chemistry and Natural Substances, Faculty of Exact Sciences and Computer University of Djelfa Djelfa Algeria.
Mohammed MessaoudiLaboratoire de Recherche sur les Produits Bioactifs et Valorisation de la Biomasse, Département de Chimie, ENS Kouba Alger Algeria.ORCID https://orcid.org/0000-0002-3536-6358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to isolate and optimize the production of L-asparaginase from fungal strains derived from Algerian Saharan plants, and evaluate the reduction of acrylamide formation in food products. L-asparaginase has frequently been used to treat childhood acute lymphoblastic leukemia. It catalyzes the hydrolysis of asparagine and glutamine into aspartic acid and ammonia. It is also used in the food industry to minimize acrylamide formation during high-temperature frying of starchy food items. In this study, L-asparaginase was identified in various microbial, animal, and plant species. Using Czapek-Dox medium, different fungal species were first isolated from Saharan plants of southeast Algeria (including

Indexed as

glucose concentrationincubation timeL‐asparaginase productionnitrogen sourcesoptimizationpH levels

Identifiers

PMID40852158
PMCPMC12368514

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.