ArticleFrontiers in medicine2025
Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Normative Heart Rate Variability Parameters Across Age and Gender in Healthy Adults from an Apex Tertiary Care Centre in Southern India.Annals of neurosciences · 2026Article
- Revealing alterations in heart rate fluctuations during the progression of Chagas disease.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Introduction: This study focused on the complex structure of heart rate variability (HRV) in the healthy heart. We studied the behavior of the heart rate variability (HRV) in healthy humans as a function of age from conception, including fetal data. We calculated statistical quantities such as the mean value of RR intervals (<RR>), the standard deviation of these intervals ( Methods: We analyzed a total of 205 HRV time series of healthy subjects. Of these time series, 195 correspond to born individuals aged between 1 month and 74 years, 50% females. The remaining ten time series correspond to healthy fetuses. The age was expressed in weeks, including gestational age to avoid finite size effects due to rounding errors. We included results previously reported in the literature. Results and discussion: <RR> followed a power law with age from gestation and throughout life. The scale factor was 0.15 ± 0.01.
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