ArticleThe Journal of comparative neurology2025
Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.
Article in The Journal of comparative neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.The Journal of comparative neurology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
The nucleus accumbens (NAcc) and ventral pallidum (VP) are key nodes in the mesolimbic reward pathway that facilitate stimulus salience, including the regulation of social motivation and attachment. Primate species display variation in social behaviors, including different levels of impulsivity, bonding, and aggression. Previous research has implicated neuromodulation of the reward pathway in the differential expression of various social behaviors, suggesting that differences in neurotransmitter innervation may play a role in species-specific patterns. To explore this, we examined serotonergic innervation in the NAcc and VP among primates. We used stereology to quantify serotonin transporter-immunoreactive (SERT-ir) axon length density in the NAcc and VP of 13 primate species, including humans, great apes, and cercopithecid and platyrrhine monkeys. Our data show that serotonergic innervation density within both the NAcc and VP is highly conserved among species. This finding contrasts with our previous findings of higher levels of SERT-ir axons in the dorsal striatum of humans and great apes relative to monkeys, a human-specific increase in dopaminergic innervation within the NAcc and VP, and a human-specific increase of neuropeptide Y in the NAcc, highlighting the mosaic nature of innervation patterns among species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.