Evidence map›Paper›PMID 40852987›Full record

ArticlemBio2025

Combinatorial effects of tryptophan derivatives serotonin and indole on virulence modulation of enteric pathogens.

Mehmet Ali Hoskan, Vanessa Sperandio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mehmet Ali HoskanDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, Wisconsin, USA.ORCID 0000-0003-2014-1233
Vanessa SperandioDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, Wisconsin, USA.ORCID 0000-0003-0819-7904

Funding

Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
Quorum Sensing Regulation of EHEC Virulence GenesR37AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VANESSA SPERANDIO · 2018 to 2026
$5.3M
Sugar regulation of EHEC virulenceR01AI154597 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MARESSO, ANTHONY W, SPERANDIO, VANESSA · 2020 to 2024
$3.1M
Tryptophan derivatives in EHEC pathogenesisR01AI155398 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2021 to 2025
$3.0M
National Institute of Allergy and Infectious Diseases AI053067National Institute of Allergy and Infectious Diseases AI154597National Institute of Allergy and Infectious Diseases AI55398NIAID NIH HHS R01 AI053067NIAID NIH HHS R01 AI154597NIAID NIH HHS R01 AI155398NIAID NIH HHS R37 AI053067
6 · The paper itself

Abstract

There is a wealth of signals present in the human gut that mediate host-microbiota communication and intersect with the gut-brain-axis. There is differential spatial localization of the tryptophan derivatives serotonin and indole in the gut, which are important cues for enteric pathogens to find their colonization niche. Both signals are sensed by enteric pathogens such as enterohemorrhagic

Indexed as

Citrobacter rodentiumEnterohemorrhagic Escherichia coliIndolesSerotoninTryptophanAnimalsDisease Models, AnimalEnterobacteriaceae InfectionsFemaleGastrointestinal MicrobiomeHumansMiceVirulenceindoleIndolesSerotoninTryptophanCitrobacter rodentiumenterohemorrhagic E. coli (EHEC)indolelocus of enterocyte effacement (LEE)serotonin

Identifiers

PMID40852987
PMCPMC12506081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.