Evidence map›Paper›PMID 40853487›Full record

ArticleNeurochemical research2025

Alamandine Rescues Cognitive Impairment and Ameliorates Alzheimer's Disease-Like Neuropathology in APP/PS1 Mice.

Shiyao Wang, Zhaohan Xu, Siyu Wang, Qiang Peng, Siqi Zhu, Caidong Liu, Yingdong Zhang, Rui Duan

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shiyao Wang *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Zhaohan Xu *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Siyu Wang *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Qiang PengDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Siqi ZhuSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210006, Jiangsu, People's Republic of China.
Caidong LiuDepartment of Blood Transfusion, Nanjing First Hospital, Pharmaceutical University, Nanjing, 210006, China.
Yingdong ZhangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Rui DuanDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. duanruicpu@163.com.

Funding

China Postdoctoral Science Foundation 2022M711666Natural Science Foundation of Jiangsu Province BK20220196the International Joint Research and Development Project of Nanjing 202201030the National Natural Science Foundation of China 82301609
6 · The paper itself

Abstract

Alzheimer's disease (AD) is on the rise worldwide, consequently driving a growing demand for effective prevention and treatment strategies. Alamandine is a member of the renin-angiotensin system family. Although alamandine exhibits protective effects in the pathophysiology of various disorders, its role in AD remains an unexplored area. This research aims to elucidate the benefits and mechanisms of alamandine in an in vivo model of AD. The mice received intracerebroventricular injections of vehicle or alamandine once daily for 4 weeks. The Morris water maze was conducted to assess spatial learning ability. Nissl staining was performed to evaluate neuronal injury. Important inflammation indictors were detected both by qRT-PCR and ELISA. Representative oxidative stress indicators and Fe

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeuroprotective AgentsOligopeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalEndoplasmic Reticulum StressMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMorris Water Maze TestOxidative StressPresenilin-1alamandineAmyloid beta-Protein PrecursorNeuroprotective AgentsOligopeptidesPresenilin-1AlamandineAlzheimer’s diseaseEndoplasmic reticulum stressFerroptosisInflammationOxidative stress

Identifiers

PMID40853487

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.