ArticleJournal of the American Chemical Society2025
Photoinduced, Copper-Catalyzed Enantioconvergent Azidation of Alkyl Halides.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes.Chemical science · 2026Article
- Organocatalytic enantioconvergent α-substitution of sulfonium salts by nitrogen nucleophiles.Chemical science · 2026Article
- Copper-Catalyzed Enantioconvergent Nucleophilic Fluorination of Alkyl Electrophiles to Generate α-Fluoroamides.Journal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Although the nucleophilic substitution of alkyl halides by azide is perhaps the most widely used method for the synthesis of organic azides, we are aware of only two reports of enantioselective variants of this classic transformation. In this study, we establish that a photoinduced chiral copper catalyst (generated in situ from commercially available components) can achieve enantioconvergent azidations of racemic secondary and tertiary alkyl halides (α-halocarbonyl compounds). The resulting enantioenriched alkyl azides are useful end points and building blocks in synthesis. Mechanistic studies furnish support for key intermediates in the proposed catalytic cycle, including copper-azide complexes and an organic radical.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.