Trial reportInternational journal of obesity (2005)2025
Differential associations of subcutaneous and visceral fat with bone turnover markers: A study on bariatric surgery patients with severe obesity and individuals without obesity.
Trial report in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Prospective Three-center Study: Laparoscopic Gastric Bypass vs. Laparoscopic Sleeve Gastrectomy in the Treatment of Morbid Obesity
Prospective, Randomised Study: Metabolic and Functional Effects of Bariatric Surgery Accessed Using PET and MRI
Who cites it
1 citing paper in PubMed.
- Regional fat distribution as a novel predictor of fracture risk in inflammatory bowel disease: a DXA-based cohort study.BMJ open gastroenterology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity suppresses bone turnover markers (BTMs) in circulation, and weight loss after metabolic and bariatric surgery (MBS) increases BTM levels. However, the relationship between regional fat distribution and BTMs has not been thoroughly investigated. This study aimed to determine which specific fat compartments - namely abdominal and femoral subcutaneous fat (SF), intraperitoneal fat, extraperitoneal fat, and total visceral fat (VF) - have the greatest impact on circulating BTM levels following weight loss induced by MBS.
methodsThe study comprised a cohort of individuals with severe obesity (n = 46) studied before and 6 months after MBS, either sleeve gastrectomy (SG, n = 25) or Roux-en-Y gastric bypass (RYGB, n = 21). Healthy individuals without obesity (n = 25) served as controls. Regional fat depots were quantified with magnetic resonance imaging. The BTMs included Tartrate-Resistant Acid Phosphatase 5b, C-terminal Telopeptide of Type I Collagen (CTX), Procollagen Type I N-terminal Propeptide (PINP), and Total (TotalOC), Carboxylated (cOC), and Undercarboxylated (ucOC) osteocalcin.
resultsIn the pooled baseline analysis, no significant associations were observed between fat depots and BTMs (all p > 0.05). Postoperatively, distinct patterns emerged between surgical groups. In the SG cohort, femoral SF was inversely associated with cOC levels (p < 0.05) compared to the RYGB group. Following RYGB, extraperitoneal, intraperitoneal, and total VF were significantly associated with TotalOC, while intraperitoneal and total VF were also negatively associated with ucOC (all p < 0.05) compared to SG. All p-values were adjusted for false discovery rate to correct for multiple comparisons.
conclusionsThe findings suggest a specific interaction between intraperitoneal, extraperitoneal, and total visceral compartments and bone metabolism following RYGB. These observed relationships highlight the need for clinicians to consider regional fat distribution when assessing bone health in post-MBS patients. CLINICALTRIALS: GOV REGISTRATION NUMBERS: NCT00793143 and NCT01373892.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.