ArticleCardiovascular diabetology2025
Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lipid biomarkers for the prediction of type 2 diabetes risk, an umbrella review and updated meta-analyses of prospective observational studies.Frontiers in endocrinology · 2026Pooled it
- Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose.Journal of diabetes investigation · 2026Article
- Atherogenic Index of Plasma as Predictor for Cardiovascular Events and Cardiometabolic Diseases:Findings from the PAMELA Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Change in circulating irisin level and its association with lipid metabolism after exenatide treatment in patients with type 2 diabetes mellitus.Journal of clinical & translational endocrinology · 2026Article
- Prognostic value of the atherogenic index of plasma in patients with multivessel coronary disease undergoing CABG: a retrospective cohort study.Lipids in health and disease · 2026Article
- Predictive value of an integrated insulin resistance and lipometabolic score for cardiometabolic multimorbidity in older adults: a UK cohort study.Cardiovascular diabetology · 2026Article
- Association between atherogenic index of plasma and hypertension in children and adolescents based on LightGBM prediction model.Scientific reports · 2026Article
- Atherogenic index of plasma is associated with poor prognosis in diabetic patients with acute kidney injury.Frontiers in endocrinology · 2026Article
- Mediation by Lipid-Glucose Metabolic Indices in the Association Between Overweight and T2DM Among Shanghai Community-Dwelling Older Adults.Journal of diabetes research · 2026Article
- Atherogenic index of plasma and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
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13 authors.
Funding
Abstract
backgroundThe global burden of type 2 diabetes mellitus (T2DM) is increasing, particularly in resource-limited settings like rural China. Although traditional blood glucose remains an essential measurement for diabetes screening, Atherogenic Index of Plasma (AIP) is emerging as a complementary predictor of T2DM risk. Over time, however, the association between AIP and T2DM risk remains insufficiently understood.
objectiveTo investigate the association between baseline AIP levels and its 5-year changes with the risk of T2DM in a rural Chinese cohort.
methodsThis prospective cohort study enrolled 14,968 participants without baseline diabetes from a rural Chinese population. AIP was calculated (log(TG/HDL-C)) and used to classify participant results into quartiles. We conducted multivariate Cox proportional hazards regression analysis, restricted cubic spline analyses, subgroup analyses, and sensitivity analyses to determine the association between baseline AIP and 5-year changes in AIP with the 10-year risk of T2DM.
resultsOver a median follow-up of 10.4 years, 2,165(N = 14,968) participants developed T2DM. The hazard ratios [aHRs; 95% confidence interval (CI)] for T2DM increased with quartiles 2, 3, and 4 (versus quartile 1) of AIP: 1.17 (1.00-1.38), 1.38 (1.18-1.62), and 1.96 (1.68-2.29), respectively (p for trend < 0.0001) after multivariable adjustment. Regarding 5-year changes in AIP, participants with increased AIP levels had a 18% higher risk of developing T2DM (aHRs 1.18, 95% CIs: 1.00-1.40) compared to those maintaining stable levels, while those with decreased AIP showed a 20% reduction in risk (aHRs 0.80, 95% CIs: 0.67-0.95). RCS analyses showed linear relationships for both baseline AIP (p for nonlinearity = 0.927) and 5-year changes in AIP (p for nonlinearity = 0.083) with T2DM risk.
conclusionsOur findings indicate that both baseline AIP levels and the 5-year changes in those levels are significantly associated with the risk of T2DM. Individuals with higher baseline AIP or 5-year increases in AIP were more likely to develop T2DM.
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