ArticleBMC neurology2025
Association between acid-suppressant use and self-reported stroke.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundThe association between proton pump inhibitors (PPIs) and stroke remains controversial, while H
methodsData on acid-suppressant use were obtained from the NHANES prescription medication survey for the past month, classifying individuals using PPIs or H2RAs as acid-suppressant users. Stroke data were derived from the disease questionnaire. Propensity score matching (PSM) was applied to reduce intergroup differences, followed by weighted multivariable logistic regression and subgroup analyses to examine the association between acid-suppressant use (including the use of PPIs and H2RAs) and stroke.
resultsA total of 54,918 participants were included before matching, among whom 5,776 (10.5%) were acid-suppressant users. Stroke was reported in 551 (9.5%) acid-suppressant users and in 1,643 (3.3%) of the 49,142 non-users. After 1:3 propensity score matching, 14,390 participants were retained, including 3,740 acid-suppressant users and 10,650 non-users. Among them, 316 users (8.4%) and 614 non-users (5.8%) reported having had a stroke. Weighted logistic regression analysis indicated a significant association between acid-suppressant use and stroke. The association remained statistically significant both before matching (OR: 1.37, 95% CI: 1.15-1.63, P < 0.001) and after matching (OR: 1.33, 95% CI: 1.10-1.60, P = 0.003). In addition, the association between H2RA use and stroke remained significant before and after matching, whereas the association between PPI use and stroke appeared less stable, showing borderline significance.
conclusionOur findings suggest a significant association between the use of acid-suppressive medications and stroke; however, due to the limitations of cross-sectional study design and self-reported data, this result requires further verification in future research.
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