Evidence map›Paper›PMID 40855533›Full record

ArticleCellular & molecular biology letters2025

Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis.

Deepika Watts, Nicolas Eberz, Mangesh T Jaykar, Anupam Sinha, Cagdas Ermis, Johanna Tiebel, Ulrike Baschant, Martina Rauner, Tatyana Grinenko, Triantafyllos Chavakis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Deepika Watts *Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Nicolas Eberz *Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Mangesh T Jaykar *Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Anupam SinhaInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Cagdas ErmisInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Johanna TiebelInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Ulrike BaschantBone Lab, MK3, Technische Universität Dresden, 01307, Dresden, Germany.
Martina RaunerBone Lab, MK3, Technische Universität Dresden, 01307, Dresden, Germany.
Tatyana GrinenkoInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Triantafyllos ChavakisInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Peter MirtschinkInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Ali El-ArmoucheDepartment of Pharmacology and Toxicology, Faculty of Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Ben WielockxInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307, Dresden, Germany. Ben.Wielockx@tu-dresden.de.ORCID http://orcid.org/0000-0002-4923-2596

Funding

Deutsche Forschungsgemeinschaft CRC/Transregio 205/2Deutsche Forschungsgemeinschaft CRC/Transregio 369Deutsche Forschungsgemeinschaft Disease"(A02)Deutsche Forschungsgemeinschaft Project No. 314061271 - TRR205Deutsche Forschungsgemeinschaft "The Adrenal: Central Relay in Health
6 · The paper itself

Abstract

backgroundGlucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood.

methodsWe used a mouse model with adrenocortical cell-specific deletion of hypoxia-inducible factor-1 alpha (HIF1α; P2H1

resultsChronic GC exposure in P2H1

conclusionsOur study reveals a critical role for chronic GC-GR signaling in modulating HSC function, promoting myeloid output, and impairing B-cell development. The P2H1

Indexed as

GlucocorticoidsHematopoiesisHypoxia-Inducible Factor 1, alpha SubunitSteroidsAnimalsB-LymphocytesHematopoietic Stem CellsMiceMice, Inbred C57BLReceptors, GlucocorticoidSignal TransductionGlucocorticoidsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitReceptors, GlucocorticoidSteroidsB cellsChronic stress hematopoiesisGlucocorticoid signalingHematopoietic stem cellsHypoxia inducible factor-1

Identifiers

PMID40855533
PMCPMC12379443

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.