Evidence map›Paper›PMID 40855979›Full record

ArticleObesity (Silver Spring, Md.)2025

CRISPLD2, a novel insulin-sensitizing adipokine that alters adipocyte size.

Beth A Griesel, Kylie Williams, Nagib Ahsan, Philipp E Scherer, Ann Louise Olson, David P Sparling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beth A GrieselDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA.
Kylie WilliamsOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA.
Nagib AhsanDepartment of Chemistry and Biochemistry, Mass Spectrometry, Proteomics and Metabolomics Core Facility, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, USA.
Philipp E SchererTouchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0003-0680-3392
Ann Louise OlsonDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA.ORCID https://orcid.org/0000-0001-9401-2317
David P SparlingDepartment of Pediatrics, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA.ORCID https://orcid.org/0000-0001-5940-1544

Funding

Visualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Veronica Galvan, William Edmund Sonntag · 2019 to 2026
$17.8M
Adiponectin, A Protein Secreted From Adipose TissueR01DK055758 · NIDDK · YESHIVA UNIVERSITY · PI SCHERER, PHILIPP E · 2000 to 2024
$10.9M
White Adipose Tissue Physiology, Mitochondrial Function and AdiponectinR01DK099110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PHILIPP E SCHERER · 2013 to 2026
$6.7M
Does age-dependent PFKFB3 down-regulation alter adipose tissue functionR03AG079945 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI OLSON, ANN LOUISE · 2023 to 2024
$145k
NIA NIH HHS R03 AG079945NIDDK NIH HHS R01 DK055758NIDDK NIH HHS R01 DK099110NIGMS NIH HHS P20 GM125528NIH HHS AG079945NIH HHS GM125528NIH HHS R01-DK099110NIH HHS R01-DK55758Oklahoma Center for the Advancement of Science and Technology HR-21-005
6 · The paper itself

Abstract

objectiveBoth obesity and adipose tissue fibrosis are associated with insulin resistance, which can improve with weight loss. We previously found increased adipocyte-specific secretion of the novel adipokine CRISPLD2 during weight loss. In this study, we further explore the function of adipose CRISPLD2, which others suggest may regulate inflammation and fibrosis in a variety of tissues.

methodsWe designed mice with adipose-specific doxycycline-inducible overexpression of CRISPLD2 (CLD2

resultsCLD2

conclusionsThese data suggest a model wherein CRISPLD2 can both regulate adipose tissue fibrosis and improve insulin sensitivity.

Indexed as

AdipocytesAdipokinesCell Adhesion MoleculesInsulin ResistanceObesity3T3-L1 CellsAdipose TissueAnimalsCell SizeDiet, High-FatFibrosisInterferon-gammaMaleMiceMice, Inbred C57BLSignal TransductionAdipokinesCell Adhesion MoleculesCORS26 protein, mouseInterferon-gamma

Identifiers

PMID40855979
PMCPMC12380202

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.