Evidence map›Paper›PMID 40855982›Full record

ArticleJournal of internal medicine2025

Longitudinal insights into the natural history of Type 2 diabetes among Koreans: A 20-year community-based prospective cohort study.

Wonsuk Choi, Joon Ho Moon, Hun Jee Choe, Howard H Chang, Dimple Kondal, K M Venkat Narayan, Nam H Cho

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Article in Journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wonsuk ChoiDepartment of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, South Korea.
Joon Ho MoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Hun Jee ChoeDepartment of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea.
Howard H ChangDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Dimple KondalPublic Health Foundation of India, New Delhi, India.
K M Venkat NarayanDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Nam H ChoDepartment of Preventive Medicine, Ajou University School of Medicine, Suwon, South Korea.

Funding

Korea Centers for Disease Control and PreventionNational Research Foundation of Korea
6 · The paper itself

Abstract

objectiveTo investigate the natural history of diabetes mellitus (DM) based on metabolic phenotypes of prediabetes in a community-based prospective study.

methodsIndividuals aged 40-69 years without DM were followed for 20 years. Glycemic parameters, including the 75 g oral glucose tolerance test, were assessed at baseline and biennially thereafter. Markov models were used to estimate each glycemic state's annual transition probabilities and average total length of residence.

resultsAmong the 7,676 participants without DM, 205 had isolated impaired fasting glucose (iIFG), and 1,753 had impaired glucose tolerance (IGT) at baseline. During the 17.5 years of follow-up, 2,313 (30.1%) cases of DM occurred. The annual transition to DM for those with iIFG was 7.7% (95% confidence interval [CI] 6.9, 8.5) and 6.9% (95% CI 6.6, 7.3) for those with IGT. In the normoglycemia ↔ iIFG → DM model, the total length in normoglycemia was 49.4 years (95% CI 47.0, 52.1), and the length in iIFG was 6.3 years (95% CI 5.9, 6.8). In the normoglycemia ↔ IGT → DM model, the total length in normoglycemia was 34.0 years (95% CI 32.4, 35.4), and the length in IGT was 11.9 years (95% CI 11.1, 12.5).

conclusionsIndividuals remained normoglycemic for long periods. However, the progression to DM occurs rapidly once prediabetes develops, regardless of the metabolic phenotype.

Indexed as

Diabetes Mellitus, Type 2Prediabetic StateAdultAgedBlood GlucoseDisease ProgressionEast Asian PeopleFemaleGlucose IntoleranceGlucose Tolerance TestHumansLongitudinal StudiesMaleMarkov ChainsMiddle AgedProspective StudiesBlood Glucosecohort studydiabetes mellitusimpaired fasting glucoseimpaired glucose toleranceprediabetes

Identifiers

PMID40855982
PMCPMC12459317

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.