ArticleJournal of clinical periodontology2025
Impaired Treg-Mediated Immune Regulation in Peri-Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Regulatory T Cells in Peri-implant Diseases: Current Osteoimmunologic Perspectives and Translational Challenges.Tissue engineering and regenerative medicine · 2026Review
- Long-Term Incidence of Peri-Implant Conditions: 25-Year Results of The Bernese Prospective Cohort Study.Clinical implant dentistry and related research · 2026Article
- Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation.International journal of implant dentistry · 2026Review
- Association of Transmucosal Emergence Geometry and Peri-Implant Diseases Prevalence Around Bone- and Tissue-Level Implants: A Cross-Sectional Study.Clinical oral implants research · 2026Article
- Crestal Bone Loss and Peri-Implant Conditions at Tissue-Level Implants: Influence of Prosthesis Type After 25 Years.Clinical implant dentistry and related research · 2026Observational
- Research advances in early diagnosis and treatment strategies for peri-implantitis: from microecology to regenerative therapy.Frontiers in cellular and infection microbiology · 2026Review
- Impaired Treg-Mediated Immune Regulation in Peri-Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses.Journal of clinical periodontology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimTo evaluate the T regulatory lymphocyte (Treg) profile and its potential contribution to peri-implant tissue destruction during peri-implantitis (PI).
methodsPI granulation tissue and crevicular fluid collected during PI surgical (PI group, n = 23) and explantation (PI-X group, n = 23) therapy, with peri-implant healthy tissue from second-stage surgery (H group, n = 20) as controls, were analysed. The inflammatory infiltrate was characterised by H&E staining. The relative expression of Treg-associated transcription factors and cytokines was assessed by RT-qPCR. Forkhead box P3 (FOXP3) and neuropilin (NPR)-1 were detected by immunohistochemistry, and interleukin (IL)-10, TGF-β1 and IL-35 by ELISA. The clinical parameters, namely probing depth (PD), bleeding on probing (BOP) and vertical defect depth (VDD), were also recorded.
resultsPI and PI-X lesions showed up-regulation of FOXP3, HELIOS and IL35B and down-regulation of NRP1 and TGFβ1 mRNA expression, compared to H tissue (p < 0.05). Significantly more FOXP3
conclusionsTreg dysfunction and altered cytokine profiles in PI are associated with inflammation and clinical disease severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.