ArticleSchizophrenia bulletin2026
Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data.
Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- Association Between Social and Role Functioning and Transition to Psychosis in the North American Prodrome Longitudinal Study Consortium.Schizophrenia bulletin · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
background and hypothesisDespite significant advances in our understanding of the clinical high risk (CHR) for psychosis state, the longer-term outcomes (5+ years) and the trajectory of diagnoses, symptoms, and psychosocial function have been seldom investigated.
objectiveHere we describe the methods for "Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis," an ongoing study that is being conducted across North American Prodrome Longitudinal Studies sites that included n = 2184 past participants (1999-2018). STUDY
designThe aims are to: (1) perform long-term assessments of individuals who previously met CHR criteria, (2) determine the 5+ year psychotic conversion rate and use previously collected longitudinal clinical, functional, neurocognitive, and biomarker data to predict longer term outcomes, and (3) investigate predictors of long-term clinical/functional outcome in CHR participants who did not convert to psychosis. STUDY
resultsPreliminary results from the first n = 504 participants demonstrate that 60% of those who previously met CHR criteria are still symptomatic. Eighteen percent of past participants converted to psychosis, half in the original studies and the remainder since last evaluated. Of those who converted to psychosis, the majority met criteria for an affective psychosis, consistent with the high rate of affective disorders (70%) in the non-converted group. An additional 7% of past participants died, substantially higher than the general population.
conclusionsThese early data highlight the potential of how this dataset, when combined with baseline data, can be used to answer new questions about the life course of high-risk youth and how we might intervene early to improve their long-term outcome.
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