Evidence map›Paper›PMID 40856576›Full record

ArticleAnnals of medicine2025

Bidirectional association of daily steps with sarcopenia: a longitudinal study.

Yilun Wang, Ziying Wu, Yuqing Zhang, Zidan Yang, Changjun Li, Jie Wei, Guanghua Lei, Chao Zeng

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yilun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-9468-4110
Ziying WuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-5127-5253
Yuqing ZhangDivision of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7638-0888
Zidan YangKey Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Changsha, China.ORCID 0000-0002-5362-2191
Changjun LiDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-2718-0921
Jie WeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-3510-8241
Guanghua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-2987-138X
Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-4889-5731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStep count is a well-established measure of physical activity, and step-based recommendations offering practical public guidance. However, the bidirectional associations between step count and sarcopenia remain unclear, limiting the application of step-based interventions for sarcopenia prevention. This study examined the directional association between daily steps and sarcopenia.

methodsData were collected from the Xiangya Step Study (a population-based longitudinal study) between January 2020 and December 2022. Average daily steps were tracked

resultsThe study included 1,281 participants (30.1% women), averaging 52.1 years. A significant bidirectional association was observed: fewer daily steps at baseline were associated with sarcopenia status one year later (cross-lagged path coefficient [β]=-1.20, 95%CI: -1.90 to -0.50,

conclusionsThis study highlights a bidirectional inverse association between average daily steps and sarcopenia. Increasing daily steps, especially to 5,000, might help mitigate sarcopenia development. Future research could explore interventions that increase daily steps to prevent sarcopenia and investigate whether sarcopenia reversal could improve physical activity levels.

Indexed as

ExerciseSarcopeniaWalkingAgedChinaFemaleHumansLogistic ModelsLongitudinal StudiesMaleMiddle AgedRisk Factorsbidirectional associationdaily stepslongitudinal studySarcopenia

Identifiers

PMID40856576
PMCPMC12302391

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.