Evidence map›Paper›PMID 40856955›Full record

ArticleEndocrine2025

Time in Tight Range (TITR) stratified by Coefficient of Variation (CV) in a cohort of patients with type 1 Diabetes Mellitus and Multiple Daily Injections. A real-life study.

Sandra Herranz-Antolín, Verónica Esteban-Monge, María Covadonga López-Virgos, Sofía Ramos-Garrido, Clara Coton-Batres, Silvia Lallena-Pérez, Miguel Torralba

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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sandra Herranz-AntolínEndocrinology and Nutrition Department, University Hospital of Guadalajara, Guadalajara, Spain. herranzantolin@yahoo.es.ORCID 0000-0002-4601-7997
Verónica Esteban-MongeInternal Medicine Department, University Hospital of Guadalajara, Guadalajara, Spain.
María Covadonga López-VirgosInternal Medicine Department, University Hospital of Guadalajara, Guadalajara, Spain.
Sofía Ramos-GarridoClinical Analysis Department, University Hospital of Guadalajara, Guadalajara, Spain.
Clara Coton-BatresNephrology Department, University Hospital of Guadalajara, Guadalajara, Spain.
Silvia Lallena-PérezEndocrinology and Nutrition Department, University Hospital of Guadalajara, Guadalajara, Spain.
Miguel TorralbaInstituto de Investigación Sanitaria de Castilla la Mancha (IDISCAM), Toledo, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objetiveTo analyze the Time in Tight Range (TITR) (70-140 mg/dL) and the relationship between TITR-Time in Range (TIR) and assess their possible differences according to Coefficient of Variation (CV) in a cohort of patients with type 1 Diabetes Mellitus (DM) and Multiple Daily Injections in real life. PATIENTS AND

methods355 adult users of Continuous Glucose Monitoring (CGM) with at least one HbA1c (October 1, 2023-October 1, 2024) and glucose data in the 90 days prior were included.

resultsAge 46.9 years (SD 13.6); 57.2% male; time of evolution 21.6 years (SD 12.6). Mean TITR was 38.4% (SD 14.6) and 20.3% had a TITR ≥ 50%. The correlation TITR-TIR was strong (β = 0.83; CI 95% 0.8-0.87; R

conclusionsThe correlation between TITR-TIR was strong and higher in patients with CV > 36%. Cutoff value for TIR to discriminate TITR ≥ 50% and factors that were associated with TITR also differ depending on CV. It is essential to take glycemic variability into account when interpreting metabolic control data.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1Hypoglycemic AgentsInsulinAdultBlood Glucose Self-MonitoringCohort StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedTime FactorsBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinCoefficient of variationContinuous glucose monitoringMultiple daily injectionsTime in rangeTime in tight range

Identifiers

PMID40856955

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.