Evidence map›Paper›PMID 40857030›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Ketamine Reverses Chronic Stress-Induced Behavioral Changes via the Expression of Ca

Joshua C Flowers, Paige E Vetter, McKennon J Wiles, Seung Hyun Roh, Ellison R Black, Evelina Bouckova, Madison H Wustrau, Rahmi Lee, Sang-Hun Lee, Seonil Kim

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. American ginseng (Journal of ginseng research · 2026
    Article
  5. Ketamine Reverses Chronic Stress-Induced Behavioral Changes via the Expression of CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua C FlowersMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, Colorado, USA.
Paige E VetterMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, Colorado, USA.
McKennon J WilesMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, Colorado, USA.
Seung Hyun RohDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Ellison R BlackDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Evelina BouckovaMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, Colorado, USA.
Madison H WustrauDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Rahmi LeeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Sang-Hun LeeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Seonil KimMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0002-0451-2180

Funding

The roles of delta-catenin in social behaviorR01MH132921 · NIMH · COLORADO STATE UNIVERSITY · PI Seonil Kim · 2024 to 2026
$1.1M
CSU | College of Veterinary Medicine and Biomedical Sciences, Colorado State University (CVMBS, CSU)Korea Ginseng Corporation (KGC)NIMH NIH HHS R01 MH132921
6 · The paper itself

Abstract

Chronic stress affects brain functions, leading to the development of mental disorders like anxiety and depression, as well as cognitive decline and social dysfunction. Among many biological changes in chronically stressed brains, disruptions in AMPA Receptor (AMPAR)-mediated synaptic transmission in the hippocampus are associated with stress responses. We have revealed that low-dose ketamine rapidly induces the expression of GluA1-containing, GluA2-lacking Ca

Indexed as

Behavior, AnimalCalciumKetamineReceptors, AMPAStress, PsychologicalAnimalsFearFemaleHippocampusMaleMiceMice, Inbred C57BLPyramidal CellsCalciumKetamineReceptors, AMPAbehaviorsCa2+‐permeable AMPA receptorschronic stressketamine

Identifiers

PMID40857030
PMCPMC12379868

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.