ArticleMedicine and science in sports and exercise2026
Sex Differences in Response to Acute Doxorubicin Cardiorespiratory Muscle Dysfunction and Preconditioning Exercise.
Article in Medicine and science in sports and exercise, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of mitochondrial ABCB7 transporter upregulation on acute doxorubicin cardiorespiratory muscle injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeDoxorubicin (DOX) is a potent chemotherapeutic agent whose clinical use is limited due to cardiorespiratory muscle toxicity. The objective of this study was to evaluate sex differences in the severity of DOX myotoxicity and to determine the effectiveness of preconditioning exercise to confer protection.
methodsAdult male and female Sprague-Dawley rats remained sedentary (Sed) or performed 2 wk of exercise preconditioning (5 d·wk -1 , 60 min·d -1 , 30 m·min -1 ) (Ex). Twenty-four hours after the final exercise bout, rats received saline (Sal) or DOX (20 mg·kg -1 IP). Forty-eight hours later, cardiac and respiratory muscle functions were assessed and tissues were collected.
resultsExercise preconditioning increased exercise tolerance in both male and female Sal- and DOX-treated rats compared with their Sed counterpart (male: Sed-DOX = 26.89 ± 2.30 min vs Ex-DOX = 39.01 ± 2.76 min; female: Sed-DOX = 24.65 ± 1 .81 min vs Ex-DOX = 45.14 ± 3.72 min). DOX reduced left ventricle fractional shortening (FS%) and maximal diaphragm muscle force production compared with Sal-treated rats in males and females, which were only prevented with exercise in female DOX-treated rats (FS% male: Sed-DOX = 35.57 ± 1.59% vs Ex-DOX = 35.12 ± 0.67%; female: Sed-DOX = 36.84 ± 1.11% vs Ex-DOX = 43.99 ± 2.56% and force male: Sed-DOX = 17.93 ± 1.13 N·cm -2 vs Ex-DOX = 20.91 ± 1.01 N·cm -2 ; female: Sed-DOX = 19.71 ± 0.68 N·cm -2 vs Ex-DOX = 22.00 ± 1.47 N·cm -2 ). These effects were associated with sex-specific differences in circulating hormones, muscle DOX accumulation, and gene expression.Conclusions: Cardiorespiratory muscle toxicity occurred after acute DOX exposure in male and female rats. Although, exercise preconditioning elicited a robust increase in cardiorespiratory endurance in both sexes, the beneficial effects of exercise on cardiac and diaphragm muscle function occurred exclusively in female rats.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.