ArticleAnalytical chemistry2025
Assessing Acetyl-Coenzyme A Carboxylase Activity and Inhibition in
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Optimizing Energy Structure in Low-Protein Diets Reduced Body Fat Deposition in Geese.Veterinary sciences · 2026Article
- Carnitine dysregulation in diabetic kidney disease: from pathogenic mechanism to precision biomarker.Journal of translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetyl-coenzyme A carboxylase (ACC) catalyzes the ATP-dependent carboxylation of acetyl-CoA into malonyl-CoA, the first step in fatty acid biosynthesis. ACC is increasingly recognized as being crucial for energy metabolism, leading to its emergence as a potential therapeutic target mainly for obesity and cancer. All previous ACC kinetics studies were conducted with pure enzyme preparations and measurements at several substrate concentrations using methods such as radioactivity counting of labeled substrate(s) and/or product(s) or UV estimation of chromatographically resolved components. In alternative, a real-time kinetics method based on HPLC or NMR monitoring was developed and successfully applied using partially purified protein extracts and a single substrate concentration. Kinetic parameters were derived for
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.