Evidence map›Paper›PMID 40858267›Full record

ArticleOpen biology2025

Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism.

Yuki Higuchi, Akihiko Ozawa, Ryuki Kobayashi, Toshihiro Konno, Hiroyuki Arakawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuki HiguchiDepartment of Systems Physiology, University of the Ryukyus School of Medicine, Nakagami-gun, Japan.
Akihiko OzawaDepartment of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA.
Ryuki KobayashiSubtropical Agro-Environmental Sciences, University of the Ryukyus - Uehara Campus, Nakagami District, Okinawa Prefecture, Japan.
Toshihiro KonnoSubtropical Agro-Environmental Sciences, University of the Ryukyus - Uehara Campus, Nakagami District, Okinawa Prefecture, Japan.
Hiroyuki ArakawaDepartment of Pharmacology, University of Michigan Medical school, Ann Arbor, MI, USA.ORCID 0000-0002-6175-9278

Funding

Serotonin mechanisms in fentanyl-induced respiratory depressionR01DA061320 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Erica Sawyer Levitt · 2024 to 2026
$1.4M
Dissecting active neural circuits regulating sensory and affective painR34NS121875 · NINDS · FLORIDA ATLANTIC UNIVERSITY · PI OZAWA, AKIHIKO · 2021 to 2021
$673k
Japan Society for the Promotion of ScienceNIDA NIH HHS R01 DA061320NINDS NIH HHS R34 NS121875
6 · The paper itself

Abstract

Oxytocin (OXT) neurons in the paraventricular nucleus of the hypothalamus (PVN), which send projections to the medial amygdala (MeA) and the bed nucleus of the stria terminalis (BnST), are implicated in regulation of prosocial-emotional behaviours and abnormalities resembling autism spectrum disorders (ASD). Compared with standard C57BL6J (B6) mice, BTBR mice, a behaviour-based ASD model, exhibited decreased densities of OXT

Indexed as

AnxietyAutism Spectrum DisorderAutistic DisorderOxytocinSocial BehaviorAmygdalaAnimalsBehavior, AnimalDisease Models, AnimalMaleMiceMice, Inbred C57BLNeuronsParaventricular Hypothalamic NucleusReceptors, OxytocinSeptal NucleiOxytocinReceptors, Oxytocinanxietyautismchemogeneticsneural circuitsoxytocinsocial behaviour

Identifiers

PMID40858267
PMCPMC12380489

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.