ArticleNature communications2025
Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Loss of Twist impairs tentacle development and induces epithelial neoplasia in the sea anemone Nematostella vectensis.Development (Cambridge, England) · 2026Article
- Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids.Nature communications · 2026Article
- Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis.EMBO reports · 2026Article
- Evolutionary rewiring of the endomesoderm gene regulatory networks specify skeleton secreting cells in stony corals.bioRxiv : the preprint server for biology · 2026Article
- Decoding cnidarian cell type gene regulation.Nature ecology & evolution · 2026Article
- The jellyfish Clytia hemisphaerica.Nature methods · 2026Article
- An abundant membrane protein in the NCAM superfamily is required for epithelial organization in sea anemone embryos.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Whole body regeneration deploys a rewired embryonic gene regulatory network logic.Nature communications · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A recent study suggested that morphologically diploblastic sea anemones (Cnidaria) have three segregated germ layer identities corresponding to the bilaterian germ layers. Here, we investigated how these germ layer identities are specified during early development of the sea anemone Nematostella vectensis. Our gene expression analysis shows that the mesodermal territory is specified at the animal pole at 6 h postfertilization, followed by the specification of the definitive endoderm between mesoderm and ectoderm. We then assessed the role of β-catenin, MAPK, and Notch signaling during mesoderm and endoderm formation. We show that the mesodermal marker genes are activated by MAPK signaling while being repressed elsewhere by β-catenin signaling. Delta-expressing mesoderm then signals to Notch-expressing ectoderm, inducing the definitive endoderm domain at the mesoderm/ectoderm interface. Gain- and loss-of-function experiments showed that Notch signaling is sufficient for endoderm induction. Based on our results, we propose a model of germ layer specification in Nematostella defined by a crosstalk of MAPK, β-catenin, and Notch signaling. Given the similarity of the germ layer specification between the sea anemone and echinoderms, we propose that triploblasty may have predated the split of cnidarians and bilaterians.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.