Evidence map›Paper›PMID 40858659›Full record

ArticleScientific reports2025

Antimicrobial and anti-biofilm activity of Hypericum brasiliense extract and its fractions on Staphylococcus of canine origin.

Yasmim de M Assumpção, Lialyz S P Andre, Izabel M Teixeira, Carolina O da Fonseca, Francisco P Machado, Tainara A N Ribeiro, Renata F A Pereira, Daniela Sachs, Leandro M Rocha, Bruno Penna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Antibacterial and Antibiofilm Activities of Bluestem (International journal of microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yasmim de M AssumpçãoGram-Positive Cocos Laboratory, Biomedical Institute, Federal Fluminense University, Niterói, RJ, 24210-130, Brazil.
Lialyz S P AndreMolecular Epidemiology and Biotechnology Laboratory, Biomedical Institute, Federal Fluminense University, Niterói, RJ, 24241-002, Brazil.
Izabel M TeixeiraGram-Positive Cocos Laboratory, Biomedical Institute, Federal Fluminense University, Niterói, RJ, 24210-130, Brazil.
Carolina O da FonsecaGram-Positive Cocos Laboratory, Biomedical Institute, Federal Fluminense University, Niterói, RJ, 24210-130, Brazil.
Francisco P MachadoNatural Products Technology Laboratory, Pharmaceutical Technology Department, Federal Fluminense University, Niterói, RJ, 24241-002, Brazil.
Tainara A N RibeiroMicrobiological Analysis Laboratory, Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, MG, 37500-903, Brazil.
Renata F A PereiraMolecular Epidemiology and Biotechnology Laboratory, Biomedical Institute, Federal Fluminense University, Niterói, RJ, 24241-002, Brazil.
Daniela SachsMicrobiological Analysis Laboratory, Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, MG, 37500-903, Brazil.
Leandro M RochaNatural Products Technology Laboratory, Pharmaceutical Technology Department, Federal Fluminense University, Niterói, RJ, 24241-002, Brazil.
Bruno PennaGram-Positive Cocos Laboratory, Biomedical Institute, Federal Fluminense University, Niterói, RJ, 24210-130, Brazil. bpenna@id.uff.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 443764/2018-2Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.328/2021
6 · The paper itself

Abstract

The growing resistance to antimicrobials, partly due to the ability to form biofilms, poses a challenge for developing new antimicrobial agents. This study assessed the antimicrobial and antibiofilm activity of Hypericum brasiliense extract, Japonicin, and Uliginosin-B against clinical isolates of S. pseudintermedius and S. coagulans from dogs. The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) were determined. In vitro antibiofilm activity was evaluated and showed promising results in young (6 h) and mature (24 h) biofilms. S. pseudintermedius and S. coagulans were highly sensitive to all tested substances. All tested isolates exhibited low MIC and MBC values, particularly for Uliginosin-B. Japonicin demonstrated higher MIC and MBC values. The analysis of antibiofilm activity revealed inhibition of biofilm formation and even disruption of pre-formed biofilms at various concentrations, including sub-inhibitory ones. H. brasiliense and its fractions exhibited antimicrobial and antibiofilm activity, offering promising prospects for treating infections caused by biofilm-forming bacteria.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBiofilmsHypericumPlant ExtractsStaphylococcusAnimalsDogsMicrobial Sensitivity TestsStaphylococcal InfectionsAnti-Bacterial AgentsAnti-Infective AgentsPlant ExtractsBiofilmHypericum brasilienseStaphylococcus coagulansStaphylococcus pseudintermedius

Identifiers

PMID40858659
PMCPMC12381168

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.