Evidence map›Paper›PMID 40858665›Full record

ArticleScientific reports2025

Serum metabolic profiling in rheumatic heart disease and degenerative aortic stenosis.

Daniel W Mutithu, Jennifer A Kirwan, Henry A Adeola, Olukayode O Aremu, Evelyn N Lumngwena, Mary Familusi, Lubbe Wiesner, Sebastian Skatulla, Richard Naidoo, Ntobeko A B Ntusi

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel W MutithuDivision of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, and Groote Schuur Hospital, Cape Town, 7925, South Africa.
Jennifer A KirwanMetabolomics Platform, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Henry A AdeolaHair and Skin Research Laboratory, Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, 7925, South Africa.
Olukayode O AremuDivision of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, and Groote Schuur Hospital, Cape Town, 7925, South Africa.
Evelyn N LumngwenaExtramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, 7501, South Africa.
Mary FamilusiComputational Continuum Mechanics Research Group, Department of Civil Engineering, Faculty of Engineering and the Built Environment, University of Cape Town, Cape Town, 7925, South Africa.
Lubbe WiesnerDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, 7925, South Africa.
Sebastian SkatullaComputational Continuum Mechanics Research Group, Department of Civil Engineering, Faculty of Engineering and the Built Environment, University of Cape Town, Cape Town, 7925, South Africa.
Richard NaidooDivision of Anatomical Pathology, Department of Pathology, University of Cape Town, and National Health Laboratory Services, Cape Town, 7925, South Africa.
Ntobeko A B NtusiDivision of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, and Groote Schuur Hospital, Cape Town, 7925, South Africa. ntobeko.ntusi@mrc.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolomics enables the characterisation of pathogenic and diagnostic biomarkers in cardiovascular disease (CVD). Given the high prevalence of rheumatic heart disease (RHD) and degenerative aortic stenosis (AS) in Africa, we investigated potential discriminant metabolic biomarkers in individuals with severe RHD and AS undergoing valve replacement and compared them to those in matched controls. Untargeted metabolomics of serum samples showed that seven metabolites that were differentially expressed in RHD patients were independent of the patients' baseline characteristics (covariates) and could differentiate RHD patients from healthy controls (AUC > 0.7). Four metabolites could differentiate AS patients from controls (AUC ≥ 0.7). Of the perturbed metabolites in RHD and AS, 7-HOCA and deoxycholate showed a moderate association with left ventricular ejection fraction. Furthermore, acylcarnitine and ketone body levels were correlated with the left ventricular mass index in RHD and left atrial area in AS patients. Elevated levels of cortisol were associated with the presence of valve calcification in RHD and AS patients. This is a pilot study on rarely studied CVD in sub-Saharan Africa. This study suggested that the metabolites altered in RHD and degenerative AS are not only associated with cardiac remodelling but also involved in major energetic pathways, amino acid metabolism, and inflammation regulation processes.

Indexed as

Aortic Valve StenosisMetabolomeMetabolomicsRheumatic Heart DiseaseAdultAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPilot ProjectsBiomarkersDegenerative aortic stenosisMetabolomicsRheumatic heart diseaseValve replacementValvular heart disease

Identifiers

PMID40858665
PMCPMC12381107

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.