Evidence map›Paper›PMID 40858751›Full record

Trial reportHypertension research : official journal of the Japanese Society of Hypertension2025

Evening home pulse pressure predicted cardiovascular events and mortality in older adults with hypertension: findings based on the STEP trial.

Yufei Ji, Xinyi Peng, Sifei Chen, Qirui Song, Jingjing Bai, Jun Cai

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yufei Ji *Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Xinyi Peng *Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Sifei Chen *Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Qirui SongHypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Jingjing BaiBeijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
Jun CaiBeijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China. caijun7879@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is a key predictor of cardiovascular disease (CVD) and mortality. Home blood pressure monitoring (HBPM) is a cost-effective way to assess CVD risk, though existing research mainly focuses on morning systolic (SBP) and diastolic (DBP) blood pressure measurements. This study aimed to evaluate whether evening pulse pressure (PP) measured at home could better predict CVD risk and mortality in Chinese older adults with hypertension. Data from the STEP trial, a multicenter, randomized controlled trial, were analyzed. Morning and evening home BP was measured twice a day at least once a week from enrollment to 12 months of follow-up, based on which PP was calculated and categorized into tertiles. The primary outcome was a composite of cardiovascular events and all-cause mortality. Among 7703 participants included in this analysis, 284 composite events occurred during a median follow-up of 3.43 years. Compared to the first tertile evening PP group, the third tertile evening PP group exhibited a 60% (HR = 1.60; 95% CI: 1.12-2.29) higher risk of primary outcome in the final adjusted model. A 26% increased risk was observed with each tertile increment (HR = 1.26; 95% CI: 1.05-1.50, P

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesCircadian RhythmHypertensionAgedAged, 80 and overFemaleHumansMaleMiddle AgedCardiovascular diseaseHome Blood Pressure MonitoringHypertensionPulse PressureRisk Prediction

Identifiers

PMID40858751
PMCPMC12586171

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.