Evidence map›Paper›PMID 40858792›Full record

ArticleInternational journal of obesity (2005)2025

The relationship between plasma sphingosine-1-phosphate, plasma apolipoprotein M, obesity, and the risk of incident type 2 diabetes: a prospective cohort study.

Kang-Chih Fan, I-Weng Yen, Chia-Hung Lin, Chung-Yi Yang, Chun-Heng Kuo, Szu-Chi Chen, Ya-Pin Lyu, Hsien-Chia Juan, Mao-Shin Lin, Shu-Huei Wang and 1 more

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Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kang-Chih FanDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.ORCID http://orcid.org/0000-0002-6993-4528
I-Weng YenGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-Hung LinDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chung-Yi YangSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.ORCID http://orcid.org/0000-0003-1697-8823
Chun-Heng KuoGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Szu-Chi ChenDepartment of Internal Medicine, Taipei City Hospital Renai Branch, Taipei, Taiwan.
Ya-Pin LyuDepartment of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Hsien-Chia JuanDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Mao-Shin LinDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shu-Huei WangDepartment of Anatomy and Cell Biology, National Taiwan University, Taipei, Taiwan.
Hung-Yuan LiDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. larsli@ntuh.gov.tw.ORCID http://orcid.org/0000-0001-9644-2855

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesType 2 diabetes (T2D) is a growing global health challenge, necessitating novel biomarkers for early risk assessment. This study investigates the associations between plasma sphingosine-1-phosphate (S1P), apolipoprotein M (ApoM), obesity measures, and the risk of incident T2D.

methodsWe utilized data from the Taiwan Lifestyle Study, a prospective cohort initiated in 2006. A total of 1207 individuals without diabetes at baseline were included. Abdominal fat distribution was assessed using computed tomography, while plasma S1P and ApoM levels were measured using ELISA.

resultsDuring an average follow-up of 5.93 years, 152 participants developed diabetes. Plasma S1P correlated with visceral, peritoneal, and retroperitoneal fat (all p < 0.001), while ApoM correlated with total, subcutaneous, and visceral fat (all p < 0.001). In adjusted models, plasma S1P significantly predicted diabetes (HR 0.52, 95% CI 0.35-0.77, p = 0.001), whereas plasma ApoM did not (HR 1.16, 95% CI 0.94-1.43, p = 0.170). The predictive model incorporating S1P showed an AUC of 0.7698 and a concordance statistic of 0.7637, outperforming traditional risk factors.

conclusionsPlasma S1P and ApoM are both associated with obesity. However, only plasma S1P is a good predictive biomarker for incident T2D, underscoring its potential for early risk assessment and intervention.

Indexed as

Apolipoproteins MDiabetes Mellitus, Type 2LysophospholipidsObesitySphingosineAdultBiomarkersFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsTaiwanApolipoproteins MAPOM protein, humanBiomarkersLysophospholipidsSphingosinesphingosine 1-phosphate

Identifiers

PMID40858792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.